Cyclic guanidine containing amino acids that promote glucocerebrosidase
AuthorsAl-Taie, Zahraa S
Coles, Simon J
Evans, Daniel M
Jones, Leigh F
Murphy, Patrick J
Nash, Robert J
Penkova, Yana B
Tizzard, Graham J
AffiliationSchool of Biological, Physical and Forensic Sciences, The University of Wolverhampton, Wulfruna Street, Wolverhampton, WV1 1LY, UK
MetadataShow full item record
AbstractNovel cyclic guanidine containing amino acids (S)-1, 2 and 3 were prepared from l-serine 5. (S)-2-Imino-3-methylimidazolidine-4-carboxylic acid hydrochloride salt 2. HCl and (3S, 6S)-3,6-bis(hydroxymethyl)-1,4-dimethylpiperazine-2,5-dione 15 showed in vitro promotion of the enzyme glucocerebrosidase.
CitationAl-Taie, Z. S., Bartholomew, B., Coles, S. J., Evans, D. M. et al. (2022) Cyclic guanidine containing amino acids that promote glucocerebrosidase, Tetrahedron, 123, Article No. 132959. DOI: 10.1016/j.tet.2022.132959
DescriptionThis is an accepted manuscript of an article published by Elsevier in Tetrahedron on 24/08/2022, available online: https://doi.org/10.1016/j.tet.2022.132959 The accepted version of the publication may differ from the final published version.
Corrigendum available at https://www.sciencedirect.com/science/article/pii/S0040402022006007
SponsorsThe authors would like to thank the Iraqi government (ZSA-T) and acknowledge the support of the Centre for Environmental Biotechnology Project part-funded by the European Regional Development Fund (ERDF) through the Welsh Government. We would like to thank the BEACON II scheme (ERDF; PJM) and the EPSRC National Mass Spectrometry Facility at Swansea.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/