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dc.contributor.authorChen, Anthony
dc.contributor.authorZhou, Weiju
dc.contributor.authorHou, Jian
dc.contributor.authorNevill, Alan M.
dc.contributor.authorDing, Yuanlin
dc.contributor.authorWan, Yuhui
dc.contributor.authorJester, Rebecca
dc.contributor.authorQin, Xia
dc.contributor.authorHu, Zhi
dc.contributor.authorChen, Ruoling
dc.date.accessioned2022-05-12T09:35:15Z
dc.date.available2022-05-12T09:35:15Z
dc.date.issued2022-04-29
dc.identifier.citationChen, A., Zhou, W., Hou, J. et al. (2022) Impact of older age adiposity on incident diabetes: A community-based cohort study in China. Diabetes & Metabolism Journal, 46(5), pp.733-746. https://doi.org/10.4093/dmj.2021.0215en
dc.identifier.issn2233-6079en
dc.identifier.pmid35487506 (pubmed)
dc.identifier.doi10.4093/dmj.2021.0215en
dc.identifier.urihttp://hdl.handle.net/2436/624752
dc.description© 2022 Korean Diabetes Association. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.4093/dmj.2021.0215en
dc.description.abstractBackground Obesity classifications vary globally and the impact of older age adiposity on incident diabetes has not been well-studied. Methods We examined a random sample of 2,809 participants aged ≥60 years in China, who were free of diabetes at baseline and were followed up for up to 10 years to document diabetes (n=178). The incidence of diabetes was assessed in relation to different cut-off points of body mass index (BMI) and waist circumference (WC) in multiple adjusted Cox regression models. Results The diabetic risk in the cohort increased linearly with the continuous and quartile variables of BMI and WC. The BMI-World Health Organization (WHO) and BMI-China criteria analysis did not show such a linear relationship, however, the BMI-Asian/Hong Kong criteria did; adjusted hazards ratio (HR) was 0.42 (95% confidence interval [CI], 0.20 to 0.90) in BMI <20 kg/m2, 1.46 (95% CI, 0.99 to 2.14) in 23-≤26 kg/m2, and 1.63 (95% CI, 1.09 to 2.45) in ≥26 kg/m2. The WC-China criteria revealed a slightly better prediction of diabetes (adjusted HRs were 1.79 [95% CI, 1.21 to 2.66] and 1.87 [95% CI, 1.22 to 2.88] in central obese action levels 1 and 2) than the WC-WHO. The combination of the BMI-Asian/Hong Kong with WC-China demonstrated the strongest prediction. There were no gender differences in the impact of adiposity on diabetes. Conclusion In older Chinese, BMI-Asian/Hong Kong criteria is a better predictor of diabetes than other BMI criterion. Its combination with WC-China improved the prediction of adiposity to diabetes, which would help manage bodyweight in older age to reduce the risk of diabetes.en
dc.description.sponsorshipThe data collection of the Anhui cohort study was funded by the Royal Society of UK, the BUPA Foundation (Grants Nos. 45NOV06, and TBF-M09-05) and Alzheimer’s Research UK (Grant No. ART/PPG2007B/2). The data analysis was supported by the Discipline Construction Project of Guangdong Medical University (4SG21276P) and the Basic and Applied Basic Research Foundation of Guangdong Province Regional Joint Fund Project (The Key Project) (2020B1515120021), China.en
dc.formatapplication/pdfen
dc.languageeng
dc.language.isoenen
dc.publisherKorean Diabetes Associationen
dc.subjectdiabetes mellitusen
dc.subjectwaist circumferenceen
dc.subjectbody mass indexen
dc.titleImpact of older age adiposity on incident diabetes: A community-based cohort study in Chinaen
dc.typeJournal articleen
dc.identifier.eissn2233-6087
dc.identifier.journalDiabetes & Metabolism Journalen
dc.date.updated2022-05-10T14:24:55Z
dc.contributor.institutionFaculty of Sciences and Technology, Middlesex University, London, UK.
pubs.place-of-publicationKorea (South)
dc.date.accepted2021-11-30
rioxxterms.funderRoyal Society of UK, the BUPA Foundation, Alzheimer’s Research UK, Guangdong Medical University, Basic and Applied Basic Research Foundation of Guangdong Province Regional Joint Fund Projecten
rioxxterms.identifier.project45NOV06, TBF-M09-05, ART/PPG2007B/2, 4SG21276P, 2020B1515120021en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc/4.0/en
rioxxterms.licenseref.startdate2022-05-12en
dc.source.volume46
dc.source.issue5
dc.source.beginpage733
dc.source.endpage746
dc.description.versionPublished version
refterms.dateFCD2022-05-12T09:34:34Z
refterms.versionFCDVoR
refterms.dateFOA2022-05-12T09:35:16Z


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