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dc.contributor.authorLuo, H
dc.contributor.authorWang, Y
dc.contributor.authorLiu, S
dc.contributor.authorChen, R
dc.contributor.authorChen, T
dc.contributor.authorYang, Y
dc.contributor.authorWang, D
dc.contributor.authorJu, S
dc.date.accessioned2021-10-07T14:49:17Z
dc.date.available2021-10-07T14:49:17Z
dc.date.issued2021-06-30
dc.identifier.citationLuo, H., Wang, Y., Liu, S., Chen, R., Chen, T., Yang, Y., Wang, D. and Ju, S. (2021) Associations between CT pulmonary opacity score on admission and clinical characteristics and outcomes in patients with COVID-19'. Internal and emergency medicine, Vol 2021.en
dc.identifier.issn1828-0447en
dc.identifier.pmid34191219 (pubmed)
dc.identifier.doi10.1007/s11739-021-02795-9en
dc.identifier.urihttp://hdl.handle.net/2436/624398
dc.descriptionThis is an accepted manuscript of an article published by Springer in Internal and Emergency Medicine on 30/06/2021, available online: https://doi.org/10.1007/s11739-021-02795-9 The accepted version of the publication may differ from the final published version.en
dc.description.abstractThis study investigated associations between chest computed tomography (CT) pulmonary opacity score on admission and clinical features and outcomes in COVID-19 patients. The retrospective multi-center cohort study included 496 COVID-19 patients in Jiangsu province, China diagnosed as of March 15, 2020. Patients were divided into four groups based on the quartile of pulmonary opacity score: ≤ 5%, 6–20%, 21–40% and 41% +. CT pulmonary opacity score was independently associated with age, single onset, fever, cough, peripheral capillary oxygen saturation, lymphocyte count, platelet count, albumin level, C-reactive protein (CRP) level and fibrinogen level on admission. Patients with score ≥ 41% had a dramatic increased risk of severe or critical illness [odds ratio (OR), 15.58, 95% confidence interval (CI) 3.82–63.53), intensive care unit (ICU)] admission (OR, 6.26, 95% CI 2.15–18.23), respiratory failure (OR, 19.49, 95% CI 4.55–83.40), and a prolonged hospital stay (coefficient, 2.59, 95% CI 0.46–4.72) compared to those with score ≤ 5%. CT pulmonary opacity score on admission, especially when ≥ 41%, was closely related to some clinical characteristics and was an independent predictor of disease severity, ICU admission, respiratory failure and long hospital stay in patients with COVID-19.en
dc.description.sponsorshipThis work was supported, in part, by the research Grant 2020YFC0843700 67 from Ministry of Science and Technology of the People’s Republic of China.en
dc.formatapplication/pdfen
dc.languageeng
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttps://link.springer.com/article/10.1007%2Fs11739-021-02795-9en
dc.subject2019-nCoVen
dc.subjectCOVID-19en
dc.subjectCTen
dc.subjectcoronavirusen
dc.subjectPrognosisen
dc.subjectPulmonary opacityen
dc.titleAssociations between CT pulmonary opacity score on admission and clinical characteristics and outcomes in patients with COVID-19en
dc.typeJournal articleen
dc.identifier.eissn1970-9366
dc.identifier.journalInternal and Emergency Medicineen
dc.date.updated2021-07-16T10:24:48Z
dc.contributor.institutionDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.
pubs.place-of-publicationItaly
dc.date.accepted2021-06-10
rioxxterms.funderMinistry of Science and Technology of the People's Republic of Chinaen
rioxxterms.identifier.project2020YFC0843700 67en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2022-06-30en
dc.description.versionPublished version
refterms.dateFCD2021-10-07T14:47:38Z
refterms.versionFCDAM


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