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dc.contributor.authorLandy, J
dc.contributor.authorAl-Hassi, Hafid Omar
dc.contributor.authorMcLaughlin, SD
dc.contributor.authorWalker, AW
dc.contributor.authorCiclitira, PJ
dc.contributor.authorNicholls, RJ
dc.contributor.authorClark, SK
dc.contributor.authorHart, AL
dc.date.accessioned2021-07-23T13:32:27Z
dc.date.available2021-07-23T13:32:27Z
dc.date.issued2011-06-20
dc.identifier.citationLandy, J., Al-Hassi, H.O., Mclaughlin, S.D., Walker, A.W., Ciclitira, P., Nicholls, R.J., Clark, S.K. and Hart, A.L. (2011) Review article: faecal transplantation therapy for gastrointestinal disease.. Alimentary Pharmacology and Therapeutics, Wiley, 2011, 34 (4), pp.409. ff10.1111/j.1365-2036.2011.04737.xen
dc.identifier.issn0269-2813en
dc.identifier.pmid21682755 (pubmed)
dc.identifier.doi10.1111/j.1365-2036.2011.04737.xen
dc.identifier.urihttp://hdl.handle.net/2436/624221
dc.descriptionThis is an accepted manuscript of an article published by Wiley in Alimentary Pharmacology and Therapeutics on 20/06/2011, available online: https://doi.org/10.1111/j.1365-2036.2011.04737.x The accepted version of the publication may differ from the final published version.en
dc.description.abstractSummary Background Evidence is emerging regarding the relationship between a dysbiosis of the human gut microbiota and a number of gastrointestinal diseases as well as diseases beyond the gut. Probiotics have been investigated in many gastrointestinal disease states, with variable and often modest outcomes. Faecal transplantation is an alternative approach to manipulate the gut microbiota. Aim To review the use of faecal transplantation therapy for the management of gastrointestinal disorders. Methods Available articles on faecal transplantation in the management of gastrointestinal disorders were identified using a Pubmed search and bibliographies of review articles on the subject were collated. Results A total of 239 patients who had undergone faecal transplantation were reported. Seventeen of 22 studies of faecal transplantation were in fulminant or refractory Clostridium difficile. Studies of faecal transplantation are heterogeneous regarding the patients, donors, screening, methods of administration and definition of response. Faecal transplantation for C. difficile has been demonstrated to be effective in 145/166 (87%) patients. Small numbers of patients are reported to have undergone successful faecal transplantation for irritable bowel syndrome and inflammatory bowel disease. Conclusions Faecal transplantation has been reported with good outcomes for fulminant and refractory C. difficile. No adverse effects of faecal transplantation have been reported. However, there are no level 1 data of faecal transplantation and reports to date may suffer from reporting bias of positive outcomes and under-reporting of adverse effects. This therapy holds great promise, where a dysbiosis of the gut microbiota is responsible for disease and further studies are necessary to explore this potential.en
dc.formatapplication/pdfen
dc.languageeng
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2011.04737.xen
dc.subject.meshGastrointestinal Tract
dc.subject.meshFeces
dc.subject.meshHumans
dc.subject.meshGastrointestinal Diseases
dc.subject.meshBacterial Physiological Phenomena
dc.subject.meshMicrobial Interactions
dc.titleReview article: faecal transplantation therapy for gastrointestinal diseaseen
dc.typeJournal articleen
dc.identifier.eissn1365-2036
dc.identifier.journalAlimentary Pharmacology and Therapeuticsen
dc.date.updated2021-07-22T10:05:25Z
dc.contributor.institutionIBD Unit, St Mark's Hospital, Harrow, London, UK.
pubs.place-of-publicationEngland
dc.date.accepted2011-05-24
rioxxterms.funderImperial College Londonen
rioxxterms.identifier.projectUOW23072021HOen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2021-07-23en
dc.source.volume34
dc.source.issue4
dc.source.beginpage409
dc.source.endpage415
dc.description.versionPublished version
refterms.dateFCD2021-07-23T13:31:06Z
refterms.versionFCDAM
refterms.dateFOA2021-07-23T13:32:27Z


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