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dc.contributor.authorTang, J
dc.contributor.authorZhu, X
dc.contributor.authorChen, Y
dc.contributor.authorHuang, D
dc.contributor.authorTiemeier, H
dc.contributor.authorChen, R
dc.contributor.authorBao, W
dc.contributor.authorZhao, Q
dc.date.accessioned2021-07-21T10:39:15Z
dc.date.available2021-07-21T10:39:15Z
dc.date.issued2021-02-15
dc.identifier.citationTang, J., Zhu, X., Chen, Y. et al. Association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes. Scientific Reports 11, 3831 (2021). https://doi.org/10.1038/s41598-021-82064-zen
dc.identifier.issn2045-2322en
dc.identifier.pmid33589654 (pubmed)
dc.identifier.doi10.1038/s41598-021-82064-zen
dc.identifier.urihttp://hdl.handle.net/2436/624208
dc.description© 2021 The Authors. Published by Springer. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1038/s41598-021-82064-zen
dc.description.abstractThis study investigated the association between pre-pregnancy body mass index (BMI) and adverse pregnancy outcomes among women participated in the National Free Preconception Health Examination Project in Guangdong Province, China, and explored these associations according to maternal age. Pre-pregnancy BMI was classified into underweight (BMI < 18.5 kg/m2), healthy weight (18.5–23.9 kg/m2), overweight (24.0–27.9 kg/m2), and obesity (≥ 28.0 kg/m2) according to Chinese criteria. Outcomes were preterm birth (PTB, delivery before 37 weeks of gestation), large for gestational age (LGA, birthweight above the 90th percentile for gestational age by infants’ sex), small for gestational age (SGA, birthweight below the 10th percentile for gestational age by infants’ sex), primary caesarean delivery, shoulder dystocia or birth injury, and stillbirth. Adjusted incidence risk ratios (aIRR) were calculated for underweight, overweight and obesity, respectively. Compared with healthy weight, underweight was associated with increased risk of PTB (aIRR 1.06, 95%CI 1.04–1.09) and SGA (1.23, 1.22–1.26) but inversely associated with LGA (0.83, 0.82–0.85), primary caesarean delivery (0.88, 0.87–0.90) and stillbirth (0.73, 0.53–0.99). Overweight was associated with increased risk of LGA (1.17, 1.14–1.19), primary caesarean delivery (1.18, 1.16–1.20) and stillbirth (1.44, 1.03–2.06), but inversely associated with SGA (0.92, 0.90–0.95) and shoulder dystocia or birth injury (0.86, 0.79–0.93). Obesity was associated with increased risk of PTB (1.12, 1.05–1.20), LGA (1.32, 1.27–1.37), primary caesarean delivery (1.45, 1.40–1.50), but inversely associated with SGA (0.92, 0.87–0.97). The aIRRs for underweight, overweight and obesity in relation to these adverse pregnancy outcomes ranged from 0.65 to 1.52 according to maternal age. In Chinese population, maternal pre-pregnancy BMI was significantly associated with the risk of adverse pregnancy outcomes and the risk differs according to maternal age. Further investigation is warranted to determine whether and how counselling and interventions for women with low or increased BMI before pregnancy can reduce the risk of adverse pregnancy outcomes.en
dc.formatapplication/pdfen
dc.languageeng
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttps://www.nature.com/articles/s41598-021-82064-zen
dc.rightsLicence for published version: Creative Commons Attribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectepidemiologyen
dc.subjectnutritionen
dc.subjectpreterm birthen
dc.subjectpreventive medicineen
dc.subjectweight managementen
dc.titleAssociation of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomesen
dc.typeJournal articleen
dc.identifier.eissn2045-2322
dc.identifier.journalScientific Reportsen
dc.date.updated2021-07-16T10:43:46Z
dc.contributor.institutionDepartment of Preventive Medicine, School of Public Health, Guangzhou Medical University, Room 507, Block 2, Xinzao, Panyu District, 511436, Guangzhou, People's Republic of China. gytanjie@163.com.
pubs.place-of-publicationEngland
dc.date.accepted2021-01-05
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW21072021RCen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2021-07-21en
dc.source.volume11
dc.source.issue1
dc.source.beginpage3831
dc.description.versionPublished version
refterms.dateFCD2021-07-21T10:39:03Z
refterms.versionFCDVoR
refterms.dateFOA2021-07-21T10:39:16Z


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Licence for published version: Creative Commons Attribution 4.0 International
Except where otherwise noted, this item's license is described as Licence for published version: Creative Commons Attribution 4.0 International