Association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes
Abstract
This study investigated the association between pre-pregnancy body mass index (BMI) and adverse pregnancy outcomes among women participated in the National Free Preconception Health Examination Project in Guangdong Province, China, and explored these associations according to maternal age. Pre-pregnancy BMI was classified into underweight (BMI < 18.5 kg/m2), healthy weight (18.5–23.9 kg/m2), overweight (24.0–27.9 kg/m2), and obesity (≥ 28.0 kg/m2) according to Chinese criteria. Outcomes were preterm birth (PTB, delivery before 37 weeks of gestation), large for gestational age (LGA, birthweight above the 90th percentile for gestational age by infants’ sex), small for gestational age (SGA, birthweight below the 10th percentile for gestational age by infants’ sex), primary caesarean delivery, shoulder dystocia or birth injury, and stillbirth. Adjusted incidence risk ratios (aIRR) were calculated for underweight, overweight and obesity, respectively. Compared with healthy weight, underweight was associated with increased risk of PTB (aIRR 1.06, 95%CI 1.04–1.09) and SGA (1.23, 1.22–1.26) but inversely associated with LGA (0.83, 0.82–0.85), primary caesarean delivery (0.88, 0.87–0.90) and stillbirth (0.73, 0.53–0.99). Overweight was associated with increased risk of LGA (1.17, 1.14–1.19), primary caesarean delivery (1.18, 1.16–1.20) and stillbirth (1.44, 1.03–2.06), but inversely associated with SGA (0.92, 0.90–0.95) and shoulder dystocia or birth injury (0.86, 0.79–0.93). Obesity was associated with increased risk of PTB (1.12, 1.05–1.20), LGA (1.32, 1.27–1.37), primary caesarean delivery (1.45, 1.40–1.50), but inversely associated with SGA (0.92, 0.87–0.97). The aIRRs for underweight, overweight and obesity in relation to these adverse pregnancy outcomes ranged from 0.65 to 1.52 according to maternal age. In Chinese population, maternal pre-pregnancy BMI was significantly associated with the risk of adverse pregnancy outcomes and the risk differs according to maternal age. Further investigation is warranted to determine whether and how counselling and interventions for women with low or increased BMI before pregnancy can reduce the risk of adverse pregnancy outcomes.Citation
Tang, J., Zhu, X., Chen, Y. et al. Association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes. Scientific Reports 11, 3831 (2021). https://doi.org/10.1038/s41598-021-82064-zPublisher
SpringerJournal
Scientific ReportsPubMed ID
33589654 (pubmed)Additional Links
https://www.nature.com/articles/s41598-021-82064-zType
Journal articleLanguage
enDescription
© 2021 The Authors. Published by Springer. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1038/s41598-021-82064-zISSN
2045-2322EISSN
2045-2322ae974a485f413a2113503eed53cd6c53
10.1038/s41598-021-82064-z
Scopus Count
Collections
Except where otherwise noted, this item's license is described as Licence for published version: Creative Commons Attribution 4.0 International
Related articles
- Association of maternal pre-pregnancy low or increased body mass index with adverse pregnancy outcomes.
- Authors: Tang J, Zhu X, Chen Y, Huang D, Tiemeier H, Chen R, Bao W, Zhao Q
- Issue date: 2021 Feb 15
- Associations of pre-pregnancy impaired fasting glucose and body mass index among pregnant women without pre-existing diabetes with offspring being large for gestational age and preterm birth: a cohort study in China.
- Authors: Tang J, Chen R, Yu Y, Bao W, Tiemeier H, Rodney A, Zhu X, Li M, Huang D, Zhao Q
- Issue date: 2021 Feb
- Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort.
- Authors: Xie D, Yang W, Wang A, Xiong L, Kong F, Liu Z, Xie Z, Wang H
- Issue date: 2021 Oct 6
- Association of Pre-Pregnancy Body Mass Index and Gestational Weight Gain with Preterm Births and Fetal Size: an Observational Study from Lebanon.
- Authors: El Rafei R, Abbas HA, Charafeddine L, Nakad P, Al Bizri A, Hamod D, Yunis KA
- Issue date: 2016 Jan