Show simple item record

dc.contributor.authorKumar, Rajiv
dc.contributor.authorGulia, Kiran
dc.date.accessioned2021-07-12T13:19:56Z
dc.date.available2021-07-12T13:19:56Z
dc.date.issued2021-05-02
dc.identifier.citationKumar, R. and Gulia, K. (2021) Cell mechanotransduction machinery, and signaling defects: small tools and nano-bio interface for influential regenerative remedies. Journal of Cell Signaling, 6(5), 233.en
dc.identifier.issn2576-1471en
dc.identifier.urihttp://hdl.handle.net/2436/624181
dc.description© 2021 The Authors. Published by Longdom Publishing. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://www.longdom.org/open-access/cell-mechanotransduction-machinery-and-cell-signaling-defects-small-tools-and-nanobio-interface-for-influential-regenera.pdfen
dc.description.abstractDesigning nanotools and devices offers a wider platform having high therapeutic claims for the discovery of drug discovery and promoting cellular events including cell motility, signaling pathways, cellular proliferation, cell physiology, apoptosis, and microenvironmental conditions during tissue engineering and regeneration. To enhance cellular environment in a physical and chemical context, the nanotools having remedies to care for the endothelial matrix during various cellular processes and mechanisms (nutrient transport, cell health, cellular interactions, differentiation, and proliferation). The influential regenerative remedies were also transported by drug delivery tools and devices for enhancing biophysical interactions with multiple mechanoresponsive that further support healing. Therefore, the small tools and nano-bio interface were also applied for stimulation and rejuvenation. The role of the Wnt/β-Catenin pathway, growth factor-β (TGF-β) signaling, inflammasome, IL-1β, cytokine, cadherin, and Ca2+dependent cell-cell adhesion proteins in the regeneration were underlined and highlighted. The elucidation of interlinked signaling pathways of cellular events offers a new approach for developing novel therapeutic remedies and emerged as new concepts in tissue regeneration and repair. Cell damage tempted injury leads to apoptosis, autophagy, and necroptosis via different processes.en
dc.formatapplication/pdfen
dc.language.isoenen
dc.publisherLongdormen
dc.relation.urlhttps://www.longdom.org/open-access/cell-mechanotransduction-machinery-and-cell-signaling-defects-small-tools-and-nanobio-interface-for-influential-regenera.pdfen
dc.subjectnano-bio interfaceen
dc.subjectcell mechanotransduction machineryen
dc.subjectintracellular signaling pathwaysen
dc.subjectnano-bio toolsen
dc.subjectfuture regenerative therapiesen
dc.titleCell mechanotransduction machinery, and signaling defects: small tools and nano-bio interface for influential regenerative remediesen
dc.typeJournal articleen
dc.identifier.journalJournal of Cell Signalingen
dc.date.updated2021-07-08T13:31:30Z
dc.identifier.articlenumber233
dc.date.accepted2021-04-28
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectSIRCen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2021-07-12en
dc.source.beginpage1
refterms.dateFCD2021-07-12T13:19:40Z
refterms.versionFCDVoR
refterms.dateFOA2021-07-12T13:19:56Z


Files in this item

Thumbnail
Name:
cell-mechanotransduction-machi ...
Size:
1.354Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/