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dc.contributor.authorMarwah, Mandeep
dc.contributor.authorMarwah, Sukhjinder
dc.contributor.authorBlann, Andrew
dc.contributor.authorMorrissey, Hana
dc.contributor.authorBall, Patrick
dc.contributor.authorWandroo, Farooq A
dc.date.accessioned2021-05-04T08:59:09Z
dc.date.available2021-05-04T08:59:09Z
dc.date.issued2021-05-03
dc.identifier.citationMarwah, M., Marwah, S., Blann, A., Morrissey, H., Ball, P. and Wandroo, F.A. (2021) Analysis of laboratory blood parameter results for patients diagnosed with COVID‐19, from all ethnic group populations: A single centre study. International Journal of Laboratory Hematology. https://doi.org/10.1111/ijlh.13538en
dc.identifier.issn1751-5521en
dc.identifier.doi10.1111/ijlh.13538en
dc.identifier.urihttp://hdl.handle.net/2436/624045
dc.description© 2021 The Authors. Published by Wiley. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1111/ijlh.13538en
dc.description.abstractIntroduction Although factors such as age, sex, diabetes, obesity and changes in certain laboratory investigations are important prognostic factors in COVID‐19 infection, these may not apply to all ethnic/racial groups. We hypothesized differences in routine biochemistry and haematology indices in Caucasian and a combined group of Black, Asian and Minority Ethnic (BAME) patients who tested positive for COVID‐19 who died, compared to survivors. Methods We tested our hypothesis in 445 patients (229 Caucasian, 216 BAME) admitted to secondary care with proven COVID‐19 infection, in whom standard routine laboratory indices were collected on admission. Results After 28 weeks, 190 (42.7%) had died within 28 days of COVID diagnosis (97 Caucasians [42.4%], 93 BAMEs [43.1%], P = .923). A general linear model analysis found the ethnicity interaction with mortality to be significant for fibrinogen, ferritin and HbA1c (after controlling for age). In a multivariate analysis, a neutrophil/lymphocyte ratio > 7.4 and a urea/albumin ratio > 0.28 increased the odds of death for both the Caucasian and the BAME group. Additional factors increasing the odds ratio in the BAME group included age >60 years and being diabetic. Conclusion Neutrophil/lymphocyte ratio and urea/albumin ratio are simple metrics that predict death to aid clinicians in determining the prognosis of COVID‐19 and help provide early intensive intervention to reduce mortality. In the BAME groups, intensive monitoring even at younger age and those with diabetes may also help reduce COVID‐19 associated mortality.en
dc.formatapplication/pdfen
dc.languageen
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1111/ijlh.13538en
dc.subjectbiochemistryen
dc.subjectCOVID-19en
dc.subjectethnic groupsen
dc.subjecthaematologyen
dc.subjectmortality indicatorsen
dc.titleAnalysis of laboratory blood parameter results for patients diagnosed with COVID‐19, from all ethnic group populations: A single centre studyen
dc.typeJournal articleen
dc.identifier.eissn1751-553X
dc.identifier.journalInternational Journal of Laboratory Hematologyen
dc.date.updated2021-05-04T07:34:36Z
dc.date.accepted2021-03-26
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW04052021HMen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2021-05-04en
dc.description.versionPublished online
refterms.dateFCD2021-05-04T08:57:41Z
refterms.versionFCDVoR
refterms.dateFOA2021-05-04T08:59:10Z


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