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dc.contributor.authorMatos, Barbara
dc.contributor.authorHowl, John
dc.contributor.authorJeronimo, Carmen
dc.contributor.authorFardilha, Margarida
dc.date.accessioned2021-04-26T08:15:09Z
dc.date.available2021-04-26T08:15:09Z
dc.date.issued2021-08-12
dc.identifier.citationMatos, B., Howl, J., Jerónimo, C. and Fardilha, M. (2021) Modulation of serine/threonine-protein phosphatase 1 (PP1) complexes: a promising approach in cancer treatment. Drug Discovery Today, 26(11), pp. 2680-2698. https://doi.org/10.1016/j.drudis.2021.08.001en
dc.identifier.issn1359-6446en
dc.identifier.doi10.1016/j.drudis.2021.08.001
dc.identifier.urihttp://hdl.handle.net/2436/624030
dc.descriptionThis is an accepted manuscript of an article published by Elsevier in Drug Discovery Today, available online at: https://doi.org/10.1016/j.drudis.2021.08.001 The accepted version of the publication may differ from the final published version.en
dc.description.abstractCancer is the second leading cause of death worldwide. Despite the numerous therapeutic options available, tumor heterogeneity and chemoresistance have limited their success and the development of an effective anticancer therapy remains a major challenge in oncology research. The serine/threonine-protein phosphatase 1 (PP1) and its complexes have been recognized as potential drug targets. Although research on the modulation of PP1 complexes is currently at an early stage, there is an immense potential. Chemically diverse compounds have been developed to disrupt or stabilize different PP1 complexes in various cancer types with the objective to inhibit disease progression. Beneficial results obtained in vitro now require further pre-clinical and clinical validation. In conclusion, the modulation of PP1 complexes seems to be a promising, albeit challenging, therapeutic strategy for cancer.en
dc.description.sponsorshipPortuguese Foundation for Science and Technology (FCT), European Union, QREN, FEDER and COMPETE funded iBiMED (UID/BIM/04501/2020, POCI-01-0145-FEDER-007628 and UID/BIM/04501/2019) and an individual scholarship from BM (SFRH/BD/146032/2019).en
dc.formatapplication/pdfen
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://www.sciencedirect.com/science/article/abs/pii/S1359644621003597?via%3Dihuben
dc.subjectPP1 complexesen
dc.subjectCancer treatmenten
dc.subjectSmall moleculesen
dc.subjectPeptidesen
dc.titleModulation of serine/threonine-protein phosphatase 1 (PP1) complexes: a promising approach in cancer treatmenten
dc.typeJournal articleen
dc.identifier.journalDrug Discovery Todayen
dc.date.updated2021-04-23T15:17:33Z
dc.date.accepted2021-04-23
rioxxterms.funderuniversity of Wolverhamptonen
rioxxterms.identifier.projectUID/BIM/04501/2020en
rioxxterms.identifier.projectPOCI-01-0145-FEDER-007628en
rioxxterms.identifier.projectUID/BIM/04501/2019en
rioxxterms.identifier.projectSFRH/BD/146032/2019en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2022-08-12en
dc.source.volume26
dc.source.issue11
dc.source.beginpage2680
dc.source.endpage2698
refterms.dateFCD2021-04-26T08:14:09Z
refterms.versionFCDAM


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