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dc.contributor.authorRabadán, MA
dc.contributor.authorCayuso, J
dc.contributor.authorLe Dréau, G
dc.contributor.authorCruz, C
dc.contributor.authorBarzi, M
dc.contributor.authorPons, S
dc.contributor.authorBriscoe, J
dc.contributor.authorMartí, E
dc.date.accessioned2021-03-29T09:34:26Z
dc.date.available2021-03-29T09:34:26Z
dc.date.issued2011-07-01
dc.identifier.citationRabadán, M., Cayuso, J., Le Dréau, G. et al. (2011) Jagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal cord. Cell Death Differ 19, 209–219 (2012). https://doi.org/10.1038/cdd.2011.84en
dc.identifier.issn1350-9047en
dc.identifier.pmid21720386 (pubmed)
dc.identifier.doi10.1038/cdd.2011.84en
dc.identifier.urihttp://hdl.handle.net/2436/623999
dc.description© 2011 The Authors. Published by Springer. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1038/cdd.2011.84en
dc.description.abstractIn the developing spinal cord, motor neurons (MNs) and oligodendrocytes arise sequentially from a common pool of progenitors. However, the genetic network responsible for this neurogenesis to gliogenesis switch is largely unknown. A transcriptome analysis identified the Notch ligand Jagged2 (JAG2) as a Sonic hedgehog-regulated factor transiently expressed in MN progenitors (pMNs). In vivo loss-and gain-of-function experiments show that JAG2 schedules the differentiation of the pMN progenitors. At early developmental stages, Olig2 expressing pMN progenitors that enter the differentiation pathway exclusively generate MNs. At these times, the activation of the Notch pathway by JAG2 maintains selected pMN progenitors in an undifferentiated state by two mechanisms; first it inhibits MN generation by reducing Olig2 proteins levels, and second it directly inhibits the premature generation of oligodendrocyte progenitors (OLPs) by maintaining high levels of Hes5. Later, extinction of JAG2 from the pMN results in the loss of Hes5 expression, heralding the gliogenic phase of pMN progenitors. Strikingly, downregulation of JAG2 in pMN progenitors is sufficient to promote the precocious generation of OLPs. Together these data provide evidence that JAG2 is a key regulator of the timely and ordered generation of two of the defining cell types in the spinal cord, MNs and OLPs. © 2012 Macmillan Publishers Limited All rights reserved.en
dc.formatapplication/pdfen
dc.languageeng
dc.language.isoenen
dc.publisherSpringer Science and Business Media LLCen
dc.relation.urlhttps://www.nature.com/articles/cdd201184en
dc.rightsLicence for published version: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectsonic hedgehogen
dc.subjectNotchen
dc.subjectOlig2en
dc.subjectHes5en
dc.subjectspinal corden
dc.subjectneurogenesisen
dc.titleJagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal corden
dc.typeJournal articleen
dc.identifier.eissn1476-5403
dc.identifier.journalCell Death and Differentiationen
dc.date.updated2021-03-24T17:35:18Z
dc.contributor.institutionInstituto de Biología Molecular de Barcelona, CSIC, Parc Científic de Barcelona, Barcelona, Spain.
pubs.place-of-publicationEngland
dc.date.accepted2011-05-13
rioxxterms.funderMedical Research Councilen
rioxxterms.identifier.projectMC_U117560541en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2021-03-29en
dc.source.volume19
dc.source.issue2
dc.source.beginpage209
dc.source.endpage219
dc.description.versionPublished version
refterms.dateFCD2021-03-29T09:34:16Z
refterms.versionFCDVoR
refterms.dateFOA2021-03-29T09:34:40Z


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Licence for published version: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Licence for published version: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International