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dc.contributor.authorCayuso, J
dc.contributor.authorDzementsei, A
dc.contributor.authorFischer, JC
dc.contributor.authorKaremore, G
dc.contributor.authorCaviglia, S
dc.contributor.authorBartholdson, J
dc.contributor.authorWright, GJ
dc.contributor.authorOber, EA
dc.date.accessioned2021-03-11T09:41:44Z
dc.date.available2021-03-11T09:41:44Z
dc.date.issued2016-11-07
dc.identifier.citationCayuso, J., Dzementsei, A., Fischer, J.C. et al. (2016) EphrinB1/EphB3b coordinate bidirectional epithelial-mesenchymal interactions controlling liver morphogenesis and laterality. Developmental Cell, 39(3), pp. 316-328.en
dc.identifier.issn1534-5807en
dc.identifier.pmid27825440 (pubmed)
dc.identifier.doi10.1016/j.devcel.2016.10.009en
dc.identifier.urihttp://hdl.handle.net/2436/623977
dc.description© 2016 The Authors. Published by Elsevier. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1016/j.devcel.2016.10.009en
dc.description.abstractPositioning organs in the body often requires the movement of multiple tissues, yet the molecular and cellular mechanisms coordinating such movements are largely unknown. Here, we show that bidirectional signaling between EphrinB1 and EphB3b coordinates the movements of the hepatic endoderm and adjacent lateral plate mesoderm (LPM), resulting in asymmetric positioning of the zebrafish liver. EphrinB1 in hepatoblasts regulates directional migration and mediates interactions with the LPM, where EphB3b controls polarity and movement of the LPM. EphB3b in the LPM concomitantly repels hepatoblasts to move leftward into the liver bud. Cellular protrusions controlled by Eph/Ephrin signaling mediate hepatoblast motility and long-distance cell-cell contacts with the LPM beyond immediate tissue interfaces. Mechanistically, intracellular EphrinB1 domains mediate EphB3b-independent hepatoblast extension formation, while EpB3b interactions cause their destabilization. We propose that bidirectional short- and long-distance cell interactions between epithelial and mesenchyme-like tissues coordinate liver bud formation and laterality via cell repulsion.en
dc.description.sponsorshipThis work was funded by the Medical Research Council ( U117581329 ), Novo Nordisk Foundation ( NNF15CC0018344 ), Danish National Research Foundation ( DNRF116 ), Wellcome Trust ( 098051 ), and an Early Postdoc Mobility Fellowship from the Swiss National Science Foundation to S.C..en
dc.formatapplication/pdfen
dc.languageeng
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://doi.org/10.1016/j.devcel.2016.10.009en
dc.rightsLicence for published version: Creative Commons Attribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectliveren
dc.subjectmorphogenesisen
dc.subjectmigrationen
dc.subjectrepulsionen
dc.subjectbidirectionalen
dc.subjectprotrusionen
dc.subjectEphrinB1en
dc.subjectEphB3en
dc.subjectlateral plate mesodermen
dc.subjectzebrafishen
dc.subject.meshLiver
dc.subject.meshEpithelium
dc.subject.meshPseudopodia
dc.subject.meshMesoderm
dc.subject.meshAnimals
dc.subject.meshZebrafish
dc.subject.meshReceptors, Eph Family
dc.subject.meshEphrin-B1
dc.subject.meshEphrin-B3
dc.subject.meshZebrafish Proteins
dc.subject.meshCell Movement
dc.subject.meshCell Shape
dc.subject.meshMorphogenesis
dc.subject.meshBody Patterning
dc.subject.meshFunctional Laterality
dc.titleEphrinB1/EphB3b coordinate bidirectional epithelial-mesenchymal interactions controlling liver morphogenesis and lateralityen
dc.typeJournal articleen
dc.identifier.eissn1878-1551
dc.identifier.journalDevelopmental Cellen
dc.date.updated2021-03-10T19:45:04Z
dc.contributor.institutionDivision of Developmental Biology, Mill Hill Laboratories, The Francis Crick Institute, London NW7 1AA, UK.
pubs.place-of-publicationUnited States
dc.date.accepted2016-10-10
rioxxterms.funderMedical Research Council, Novo Nordisk Foundation, Danish National Research Foundation, Wellcome Trust, Swiss National Science Foundationen
rioxxterms.identifier.project098051en
rioxxterms.identifier.projectOber group NNFen
rioxxterms.identifier.projectU117581329en
rioxxterms.identifier.projectNNF15CC0018344en
rioxxterms.identifier.projectMC_U117581329en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2021-03-11en
dc.source.volume39
dc.source.issue3
dc.source.beginpage316
dc.source.endpage328
dc.description.versionPublished version
refterms.dateFCD2021-03-11T09:41:13Z
refterms.versionFCDVoR
refterms.dateFOA2021-03-11T09:41:45Z


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Licence for published version: Creative Commons Attribution 4.0 International
Except where otherwise noted, this item's license is described as Licence for published version: Creative Commons Attribution 4.0 International