Future directions and requirements for tissue engineering biomaterials
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Abstract
A wide array of biomaterials are being developed to be used as tissue engineering scaffolds, including metals, ceramics, polymers, and composites. For all biomaterials, the challenge remains to achieve functionality to mimic the biomechanical environment, induce bioactivity, and support critical size tissue reintegration. This calls for a functional evolution in biomaterials to be used as tissue engineering constructs for partial and full tissue reconstruction. When characterizing biomaterials for tissue engineering, the relevant extensions include engineered surfaces, micro-patterns, and porous architectures along with, bioactive, bioresorbable, and infection resistant properties. Accordingly, functional biomaterials will drive the next generation of tissue engineering constructs. This paper, therefore, explores the major concepts, future direction, and recent signs of progress in the field of tissue engineering biomaterials. Traditional materials are not discounted entirely as bioinert materials are still relevant and emerging research offers new functionalities for them to support drug, gene, and cell tissue engineering. Therefore, an attempt is also made to explain how the requirements of biomaterials are changing to facilitate, sustain, control, and proliferate engineered tissue. The article begins with a brief introduction to the evolution of biomaterials followed by a commentary on their functional requirements when applied to tissue engineering. This is followed by an exploratory evaluation of key tissue engineering constructs and their qualifiers while systematically identifying their future direction and potential.Citation
Arjunan, A., Baroutaji, A., Praveen, A.S. et al. (2021) Future directions and requirements for tissue engineering biomaterials. Reference Module in Materials Science and Materials Engineering. https://doi.org/10.1016/B978-0-12-815732-9.00068-1Publisher
ElsevierJournal
Reference Module in Materials Science and Materials EngineeringType
Chapter in bookLanguage
enDescription
This is an accepted manuscript of an article published by Elsevier in Reference Module in Materials Science and Materials Engineering, available online: https://doi.org/10.1016/B978-0-12-815732-9.00068-1 The accepted version of the publication may differ from the final published version.ISBN
9780128035818ae974a485f413a2113503eed53cd6c53
10.1016/b978-0-12-815732-9.00068-1
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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/