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dc.contributor.authorZięba, Magdalena
dc.contributor.authorWłodarczyk, Jakub
dc.contributor.authorGupta, Abhishek
dc.contributor.authorPastusiak, Małgorzata
dc.contributor.authorChaber, Paweł
dc.contributor.authorJaneczek, Henryk
dc.contributor.authorMusioł, Marta
dc.contributor.authorSikorska, Wanda
dc.contributor.authorKaczmarczyk, Bożena
dc.contributor.authorRadecka, Izabela
dc.contributor.authorKowalczuk, Marek
dc.contributor.authorSavickas, Arunas
dc.contributor.authorSavickiene, Nijole
dc.contributor.authorAdamus, Grazyna
dc.date.accessioned2021-02-16T14:44:58Z
dc.date.available2021-02-16T14:44:58Z
dc.date.issued2021-02-10
dc.identifier.citationZięba, M., Włodarczyk, J., Gupta, A. et al. (2021) Bioresorbable electrospun mats of poly(D, L)-lactide / poly[(R, S)-3-hydroxybutyrate] blends for potential use in the treatment of difficult-to-heal skin wounds. European Polymer Journal.en
dc.identifier.issn0014-3057en
dc.identifier.doi10.1016/j.eurpolymj.2021.110334en
dc.identifier.urihttp://hdl.handle.net/2436/623933
dc.descriptionThis is an accepted manuscript of an article published by Elsevier in European Polymer Journal, available online: https://doi.org/10.1016/j.eurpolymj.2021.110334 The accepted version of the publication may differ from the final published version.en
dc.description.abstractThis study describes the preparation, physicochemical characterization and the biological studies of the polymeric delivery systems of proanthocyanidins (PCAN) extracted from Pelargonium sidoides for the potential use as wound dressings. In this study 20 wt% PCAN demonstrated good antimicrobial activity against Staphylococcus aures, a gram-positive wound pathogen. Poly(D,L-lactide) and atactic poly[(R,S)-3-hydroxybutyrate] biopolymers were used to construct biodegradable dressings. A series of polylactide/poly[(R,S)-3-hydroxybutyrate] (P(D,L)LA/a-PHB) blends, containing 10, 20, and 30 wt% of a-PHB were prepared and characterized by means of NMR, GPC, FT-IR, and DSC. Based on the findings, the P(D,L)LA/a-PHB [70/30 wt%] blend with the best thermomechanical properties (Tg value equal 37 °C) was chosen for the preparation of two kinds of electrospun mats, both with and without PCAN. About 50 % of PCAN was released from the tested mats during the first 10-12 days of incubation. The electrospun mats with elastic properties, ensuring compatibility with the wound topology, were obtained. The studies of hydrolytic degradation of the constructed mats allowed us to gain complete knowledge of their hydrolysis process, and examine the PCAN release profile as well as identify and characterize the molecular structure of the degradation products of the developed delivery system. Furthermore, preliminary cytotoxicity MTT tests (in vitro) results support the potential application of PCAN-loaded (P(D,L)LA/a-PHB) electrospun mats in wound dressings.en
dc.formatapplication/pdfen
dc.languageen
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0014305721000689?via%3Dihub#!en
dc.subjectbioresorbable polyestersen
dc.subjectaliphatic polyestersen
dc.subjectblends of poly(D,L-lactide)/poly[(R,S)-3-hydroxybutyrateen
dc.subjectproanthocyanidinsen
dc.subjectpolyester electrospun matsen
dc.subjectbioresorbable polymeric wound dressingen
dc.titleBioresorbable electrospun mats of poly(D, L)-lactide / poly[(R, S)-3-hydroxybutyrate] blends for potential use in the treatment of difficult-to-heal skin woundsen
dc.typeJournal articleen
dc.identifier.journalEuropean Polymer Journalen
dc.date.updated2021-02-11T16:12:36Z
dc.date.accepted2021-02-01
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW16022021IRen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2022-08-10en
dc.source.beginpage110334
dc.source.endpage110334
dc.description.versionPublished version
refterms.dateFCD2021-02-16T14:44:23Z
refterms.versionFCDAM


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