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dc.contributor.authorFlouris, AD
dc.contributor.authorMetsios, GS
dc.contributor.authorCarrill, AE
dc.contributor.authorJamurtas, AZ
dc.contributor.authorStivaktakis, PD
dc.contributor.authorTzatzarakis, MN
dc.contributor.authorTsatsakis, AM
dc.contributor.authorKoutedakis, Y
dc.date.accessioned2021-01-25T12:36:23Z
dc.date.available2021-01-25T12:36:23Z
dc.date.issued2012-02-15
dc.identifier.citationFlouris AD, Metsios GS, Carrill AE, Jamurtas AZ, Stivaktakis PD, Tzatzarakis MN, et al. (2012) Respiratory and Immune Response to Maximal Physical Exertion following Exposure to Secondhand Smoke in Healthy Adults. PLoS ONE 7(2): e31880. https://doi.org/10.1371/journal.pone.0031880en
dc.identifier.issn1932-6203en
dc.identifier.pmid22355401 (pubmed)
dc.identifier.doi10.1371/journal.pone.0031880en
dc.identifier.urihttp://hdl.handle.net/2436/623893
dc.description© 2012 The Authors. Published by PLOS. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1371/journal.pone.0031880en
dc.description.abstractWe assessed the cardiorespiratory and immune response to physical exertion following secondhand smoke (SHS) exposure through a randomized crossover experiment. Data were obtained from 16 (8 women) non-smoking adults during and following a maximal oxygen uptake cycling protocol administered at baseline and at 0-, 1-, and 3- hours following 1-hour of SHS set at bar/restaurant carbon monoxide levels. We found that SHS was associated with a 12% decrease in maximum power output, an 8.2% reduction in maximal oxygen consumption, a 6% increase in perceived exertion, and a 6.7% decrease in time to exhaustion (P<0.05). Moreover, at 0-hours almost all respiratory and immune variables measured were adversely affected (P<0.05). For instance, FEV 1 values at 0-hours dropped by 17.4%, while TNF-α increased by 90.1% (P<0.05). At 3-hours mean values of cotinine, perceived exertion and recovery systolic blood pressure in both sexes, IL4, TNF-α and IFN-γ in men, as well as FEV 1/FVC, percent predicted FEV 1, respiratory rate, and tidal volume in women remained different compared to baseline (P<0.05). It is concluded that a 1-hour of SHS at bar/restaurant levels adversely affects the cardiorespiratory and immune response to maximal physical exertion in healthy nonsmokers for at least three hours following SHS. © 2012 Flouris et al.en
dc.formatapplication/pdfen
dc.languageeng
dc.language.isoenen
dc.publisherPublic Library of Science (PLoS)en
dc.relation.urlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031880en
dc.rightsLicence for published version: Creative Commons Attribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshHumans
dc.subject.meshCotinine
dc.subject.meshCytokines
dc.subject.meshRespiratory Function Tests
dc.subject.meshVital Capacity
dc.subject.meshExercise
dc.subject.meshCross-Over Studies
dc.subject.meshSingle-Blind Method
dc.subject.meshTobacco Smoke Pollution
dc.subject.meshEnvironmental Exposure
dc.subject.meshBlood Pressure
dc.subject.meshAdult
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshImmunity, Innate
dc.subject.meshRespiratory Physiological Phenomena
dc.subject.meshYoung Adult
dc.titleRespiratory and immune response to maximal physical exertion following exposure to secondhand smoke in healthy adultsen
dc.typeJournal articleen
dc.identifier.eissn1932-6203
dc.identifier.journalPLoS ONEen
dc.date.updated2021-01-24T19:52:27Z
dc.contributor.institutionFAME Laboratory, Institute of Human Performance and Rehabilitation, Centre for Research and Technology, Thessaly, Greece. andreasflouris@gmail.com
pubs.place-of-publicationUnited States
dc.date.accepted2012-01-19
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW25012021YKen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2021-01-25en
dc.source.volume7
dc.source.issue2
dc.source.beginpagee31880
dc.description.versionPublished version
refterms.dateFCD2021-01-25T12:36:13Z
refterms.versionFCDVoR
refterms.dateFOA2021-01-25T12:36:24Z


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Licence for published version: Creative Commons Attribution 4.0 International
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