Characterization of bacterial cellulose-based wound dressing in different order impregnation of chitosan and collagen
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Issue Date
2020-11-03
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Show full item recordAbstract
Bacterial cellulose (BC), chitosan (Chi), and collagen (Col) are known as biopolymers which have met some properties that are required as wound dressing. This study focused on investigating the fabrication of BC-based wound dressing with chitosan and collagen, since chitosan has red blood cells binding and anti-bacterial properties, while collagen can support cell and tissue growth for skin wounds. The BC-based wound dressing was prepared by impregnating BC fibers in the chitosan and/or collagen solution for 24 h. FTIR was used to confirm the intermolecular interaction of amine and hydroxyl group of chitosan and/or collagen in BC-based wound dressing. Furthermore, the XRD diffractogram of the wound dressing show broader peaks at 14.2°, 16.6°, and 22.4° due to the presence of chitosan and collagen molecules in BC fibers. These results were then supported by SEM images which confirmed that chitosan and collagen were well penetrated into BC fibers. TGA curves revealed that BC/Chi/Col has better thermal properties based on the Tmax compare to BC/Col/Chi. Feasibility of the mats to be applied as wound dressing was also supported by other tests, i.e., water content, porosity, and hemocompatibility, which indicates that the wound dressing is classified as nonhemolytic materials. However, BC/Col/Chi was considered a more potential wound dressing to be applied compared to BC/Chi/Col since it has larger pores and showed better antibacterial properties (larger zones of inhibition) against S. aureus and E. coli via disk diffusion tests.Citation
Pasaribu, K.M., Gea, S., Ilyas, S., Tamrin, T. and Radecka, I. (2020) Characterization of Bacterial Cellulose-Based Wound Dressing in Different Order Impregnation of Chitosan and Collagen. Biomolecules 2020, 10, 1511.Publisher
MDPIJournal
BiomoleculesAdditional Links
https://www.mdpi.com/2218-273X/10/11/1511Type
Journal articleLanguage
enDescription
© 2020 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/biom10111511ISSN
2218-273XEISSN
2218-273Xae974a485f413a2113503eed53cd6c53
10.3390/biom10111511
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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/