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dc.contributor.authorAl-Abadie, Mohammed
dc.contributor.authorOumeish, Faris
dc.contributor.authorAl-Rubaye, Mohammed
dc.contributor.authorRafiq, Shahid
dc.contributor.authorBall, Patrick
dc.contributor.authorMorrissey, Hana
dc.date.accessioned2020-11-13T09:55:53Z
dc.date.available2020-11-13T09:55:53Z
dc.date.issued2020-12-31
dc.identifier.citationAl-Abadie, M., Oumeish, F., Al-Rubaye, M., Shafiq, S., Ball, P.A., and Morrissey, H. (in press) Vitamin A derivatives use in the treatment of skin conditions, International Journal of Current Pharmaceutical Research.en
dc.identifier.issn0975-7066en
dc.identifier.urihttp://hdl.handle.net/2436/623770
dc.description.abstractRetinoids are used to treat various skin diseases. They add valuable impact of when used early in the treatment of dermatological conditions. Overall vitamin A derivatives are underused, with isotretinoin is the most used. This paper aims to develop prescribers’ knowledge about their benefits, to improve their usability and aids in alleviating patient concerns to improve therapeutic outcomes in dermatological conditions. In acne vulgaris, adapalene gel and tretinoin cream showed equal efficacy. In psoriasis the combination of acitretin and PUVA was superior to PUVA alone. Acitretin showed a reduction of 41% in the Nail Psoriasis Severity Index and similar efficacy to potent steroids and calcipotriol. In chronic hand eczema, alitretinoin showed 50% improvement in patient’s refractory to steroid treatment. In photoaging and aging, retinoids were shown to increase the synthesis and decrease the degradation rate of collagen and hyaluronate, reducing the impact of aging. In rosacea, topical and systemic isotretinoin showed complete remission in 24% of the patients compared to only 14 % with antibiotics (metronidazole and doxycycline). In lichen planus, isotretinoin demonstrated clinical and histopathological efficacy. In cutaneous T-cell lymphoma, bexarotene used alone or with PUVA or narrow band UVB, showed a response between 80.0% to 84.0%. Lastly in Kaposi sarcoma alitretinoin gel showed superiority to all other agents and better tolerance. This review highlights the benefit of timely use of vitamin A derivatives to encourage wider use.en
dc.formatapplication/pdfen
dc.languageEnglish
dc.language.isoenen
dc.publisherInnovare Academic Sciencesen
dc.relation.urlhttps://innovareacademics.in/journals/index.php/ijcpr/abouten
dc.subjectIsotretinoinen
dc.subjectVitamin Aen
dc.subjectAcne Vulgarisen
dc.subjectPsoriasisen
dc.subjectPhotoagingen
dc.subjectAgingen
dc.titleVitamin A derivatives use in the treatment of skin conditionsen
dc.typeJournal articleen
dc.identifier.journalInternational Journal of Current Pharmaceutical Researchen
dc.date.updated2020-11-09T08:48:07Z
dc.date.accepted2020-09-11
rioxxterms.funderuNIVERSITY OF wOLVERHAMPTONen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2020-12-31en
refterms.dateFCD2020-11-13T09:51:00Z
refterms.versionFCDVoR


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