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dc.contributor.authorChen, Ruoling
dc.contributor.authorWilson, Kenneth
dc.contributor.authorChen, Yang
dc.contributor.authorZhang, Dongmei
dc.contributor.authorQin, Xia
dc.contributor.authorHe, M
dc.contributor.authorHu, Zhi
dc.contributor.authorMa, Ying
dc.contributor.authorCopeland, John R
dc.date.accessioned2020-09-18T14:47:19Z
dc.date.available2020-09-18T14:47:19Z
dc.date.issued2013-01-01
dc.identifier.citationChen R,. Wilson K., Chen Y., Zhang, D. et al (2013) Association between environmental tobacco smoke exposure and dementia syndromes, Occupational and Environmental Medicine 70 (1) pp.63-69. DOI: 10.1136/oemed-2012-100785
dc.identifier.issn1351-0711
dc.identifier.pmid23104731 (pubmed)
dc.identifier.doi10.1136/oemed-2012-100785
dc.identifier.urihttp://hdl.handle.net/2436/623653
dc.description© 2020 The Authors. Published by BMJ. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: http://dx.doi.org/10.1136/oemed-2012-100785
dc.description.abstractObjectives: Environmental tobacco smoke (ETS) has a range of adverse health effects, but its association with dementia remains unclear and with dementia syndromes unknown. We examined the dose-response relationship between ETS exposure and dementia syndromes. Methods: Using a standard method of GMS, we interviewed 5921 people aged ≥60 years in five provinces in China in 2007-2009 and characterised their ETS exposure. Five levels of dementia syndrome were diagnosed using the Automated Geriatric Examination for Computer Assisted Taxonomy instrument. The relative risk (RR) of moderate (levels 1-2) and severe (levels 3-5) dementia syndromes among participants exposed to ETS was calculated in multivariate adjusted regression models. Results: 626 participants (10.6%) had severe dementia syndromes and 869 (14.7%) moderate syndromes. Participants exposed to ETS had a significantly increased risk of severe syndromes (adjusted RR 1.29, 95% CI 1.05 to 1.59). This was dose-dependently related to exposure level and duration. The cumulative exposure dose data showed an adjusted RR of 0.99 (95% CI 0.76 to 1.28) for >0-24 level years of exposure, 1.15 (95% CI 0.93 to 1.42) for 25-49 level years, 1.18 (95% CI 0.87 to 1.59) for 59-74 level years, 1.39 (95% CI 1.03 to 1.84) for 75-99 level years and 1.95 (95% CI 1.34 to 2.83) for ≥100 level years. Significant associations with severe syndromes were found in never smokers and in former/current smokers. There were no positive associations between ETS and moderate dementia syndromes. Conclusions: ETS should be considered an important risk factor for severe dementia syndromes. Avoidance of ETS may reduce the rates of severe dementia syndromes worldwide.
dc.languageeng
dc.publisherBMJ
dc.rightsLicence for published version: Creative Commons Attribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.meshHumans
dc.subject.meshDementia
dc.subject.meshSyndrome
dc.subject.meshAir Pollutants
dc.subject.meshGeriatric Assessment
dc.subject.meshSeverity of Illness Index
dc.subject.meshMultivariate Analysis
dc.subject.meshRisk Factors
dc.subject.meshSmoking
dc.subject.meshTobacco Smoke Pollution
dc.subject.meshEnvironmental Exposure
dc.subject.meshTime Factors
dc.subject.meshAged
dc.subject.meshMiddle Aged
dc.subject.meshChina
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshInterviews as Topic
dc.titleAssociation between environmental tobacco smoke exposure and dementia syndromes
dc.typeJournal article
dc.identifier.eissn1470-7926
dc.identifier.journalOccupational and Environmental Medicine
dc.date.updated2020-09-16T21:21:51Z
dc.contributor.institutionSchool of Health Administration, Anhui Medical University, Hefei, China. ruoling.chen@kcl.ac.uk
pubs.place-of-publicationEngland
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.source.volume70
dc.source.issue1
dc.source.beginpage63
dc.source.endpage69
dc.description.versionPublished version
refterms.dateFOA2020-09-18T14:47:20Z


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Licence for published version: Creative Commons Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's license is described as Licence for published version: Creative Commons Attribution-NonCommercial 4.0 International