Association between environmental tobacco smoke exposure and dementia syndromes
dc.contributor.author | Chen, Ruoling | |
dc.contributor.author | Wilson, Kenneth | |
dc.contributor.author | Chen, Yang | |
dc.contributor.author | Zhang, Dongmei | |
dc.contributor.author | Qin, Xia | |
dc.contributor.author | He, M | |
dc.contributor.author | Hu, Zhi | |
dc.contributor.author | Ma, Ying | |
dc.contributor.author | Copeland, John R | |
dc.date.accessioned | 2020-09-18T14:47:19Z | |
dc.date.available | 2020-09-18T14:47:19Z | |
dc.date.issued | 2013-01-01 | |
dc.identifier.citation | Chen R,. Wilson K., Chen Y., Zhang, D. et al (2013) Association between environmental tobacco smoke exposure and dementia syndromes, Occupational and Environmental Medicine 70 (1) pp.63-69. DOI: 10.1136/oemed-2012-100785 | |
dc.identifier.issn | 1351-0711 | |
dc.identifier.pmid | 23104731 (pubmed) | |
dc.identifier.doi | 10.1136/oemed-2012-100785 | |
dc.identifier.uri | http://hdl.handle.net/2436/623653 | |
dc.description | © 2020 The Authors. Published by BMJ. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: http://dx.doi.org/10.1136/oemed-2012-100785 | |
dc.description.abstract | Objectives: Environmental tobacco smoke (ETS) has a range of adverse health effects, but its association with dementia remains unclear and with dementia syndromes unknown. We examined the dose-response relationship between ETS exposure and dementia syndromes. Methods: Using a standard method of GMS, we interviewed 5921 people aged ≥60 years in five provinces in China in 2007-2009 and characterised their ETS exposure. Five levels of dementia syndrome were diagnosed using the Automated Geriatric Examination for Computer Assisted Taxonomy instrument. The relative risk (RR) of moderate (levels 1-2) and severe (levels 3-5) dementia syndromes among participants exposed to ETS was calculated in multivariate adjusted regression models. Results: 626 participants (10.6%) had severe dementia syndromes and 869 (14.7%) moderate syndromes. Participants exposed to ETS had a significantly increased risk of severe syndromes (adjusted RR 1.29, 95% CI 1.05 to 1.59). This was dose-dependently related to exposure level and duration. The cumulative exposure dose data showed an adjusted RR of 0.99 (95% CI 0.76 to 1.28) for >0-24 level years of exposure, 1.15 (95% CI 0.93 to 1.42) for 25-49 level years, 1.18 (95% CI 0.87 to 1.59) for 59-74 level years, 1.39 (95% CI 1.03 to 1.84) for 75-99 level years and 1.95 (95% CI 1.34 to 2.83) for ≥100 level years. Significant associations with severe syndromes were found in never smokers and in former/current smokers. There were no positive associations between ETS and moderate dementia syndromes. Conclusions: ETS should be considered an important risk factor for severe dementia syndromes. Avoidance of ETS may reduce the rates of severe dementia syndromes worldwide. | |
dc.language | eng | |
dc.publisher | BMJ | |
dc.rights | Licence for published version: Creative Commons Attribution-NonCommercial 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Dementia | |
dc.subject.mesh | Syndrome | |
dc.subject.mesh | Air Pollutants | |
dc.subject.mesh | Geriatric Assessment | |
dc.subject.mesh | Severity of Illness Index | |
dc.subject.mesh | Multivariate Analysis | |
dc.subject.mesh | Risk Factors | |
dc.subject.mesh | Smoking | |
dc.subject.mesh | Tobacco Smoke Pollution | |
dc.subject.mesh | Environmental Exposure | |
dc.subject.mesh | Time Factors | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | China | |
dc.subject.mesh | Female | |
dc.subject.mesh | Male | |
dc.subject.mesh | Interviews as Topic | |
dc.title | Association between environmental tobacco smoke exposure and dementia syndromes | |
dc.type | Journal article | |
dc.identifier.eissn | 1470-7926 | |
dc.identifier.journal | Occupational and Environmental Medicine | |
dc.date.updated | 2020-09-16T21:21:51Z | |
dc.contributor.institution | School of Health Administration, Anhui Medical University, Hefei, China. ruoling.chen@kcl.ac.uk | |
pubs.place-of-publication | England | |
rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by-nc/3.0/ | |
dc.source.volume | 70 | |
dc.source.issue | 1 | |
dc.source.beginpage | 63 | |
dc.source.endpage | 69 | |
dc.description.version | Published version | |
refterms.dateFOA | 2020-09-18T14:47:20Z |