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dc.contributor.authorMcCarthy, Neil
dc.contributor.authorStagg, Andrew
dc.contributor.authorPrice, Claire
dc.contributor.authorMann, Elizabeth
dc.contributor.authorGellatly, Nichola
dc.contributor.authorAl-Hassi, Hafid
dc.contributor.authorKnight, Stella
dc.contributor.authorPanoskaltsis, Nicki
dc.date.accessioned2020-09-14T09:50:47Z
dc.date.available2020-09-14T09:50:47Z
dc.date.issued2020-10-13
dc.identifier.citationMcCarthy, N.E., Stagg, A.J., Price, C.L. et al. (2020) Patients with gastrointestinal irritability after TGN1412-induced cytokine 2 storm displayed selective expansion of gut-homing αβ and γδ T-cells, Cancer Immunology Immunotherapy. https://doi.org/10.1007/s00262-020-02723-4en
dc.identifier.issn0340-7004en
dc.identifier.doi10.1007/s00262-020-02723-4
dc.identifier.urihttp://hdl.handle.net/2436/623628
dc.descriptionThis is an accepted manuscript of an article published by Springer in Cancer Immunology, Immunotherapy, available online at: https://doi.org/10.1007/s00262-020-02723-4 The accepted version of the publication may differ from the final published versionen
dc.description.abstractFollowing infusion of the anti-CD28 superagonist monoclonal antibody TGN1412, three of six previously healthy, young male recipients developed gastrointestinal irritability associated with increased expression of ‘gut-homing’ integrin β7 on peripheral blood αβT-cells. This subset of patients with intestinal symptoms also displayed a striking and persistent expansion of putative Vδ2+ 7 γδT-cells in the circulation which declined over a two-year period following drug infusion, concordant with subsiding gut symptoms. These data demonstrate that TGN1412-induced gastrointestinal symptoms were associated with dysregulation of the ‘gut-homing’ pool of blood αβ and γδT11 cells, induced directly by the antibody and/or arising from the subsequent cytokine storm.en
dc.formatapplication/pdfen
dc.languageEnglish
dc.language.isoenen
dc.publisherSpringer Natureen
dc.relation.urlhttps://link.springer.com/article/10.1007%2Fs00262-020-02723-4en
dc.subjectcytokine stormen
dc.subjectCytokine Release Syndromeen
dc.subjectTGN1412en
dc.subjectVδ2+ 30 γδT-cellsen
dc.subjectImmune-related adverse events (irAEs)en
dc.subjectimmunotherapyen
dc.titlePatients with gastrointestinal irritability after TGN1412-induced cytokine 2 storm displayed selective expansion of gut-homing αβ and γδ T-cellsen
dc.typeJournal articleen
dc.identifier.journalCancer Immunology Immunotherapyen
dc.date.updated2020-09-04T19:24:42Z
dc.date.accepted2020-09-11
rioxxterms.funderCancer Research UKen
rioxxterms.identifier.projectUOW14092020HOen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2021-09-14en
dc.source.volume2020
dc.source.beginpage1
refterms.dateFCD2020-09-14T09:43:53Z
refterms.versionFCDAM


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