Patients with gastrointestinal irritability after TGN1412-induced cytokine 2 storm displayed selective expansion of gut-homing αβ and γδ T-cells
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AbstractFollowing infusion of the anti-CD28 superagonist monoclonal antibody TGN1412, three of six previously healthy, young male recipients developed gastrointestinal irritability associated with increased expression of ‘gut-homing’ integrin β7 on peripheral blood αβT-cells. This subset of patients with intestinal symptoms also displayed a striking and persistent expansion of putative Vδ2+ 7 γδT-cells in the circulation which declined over a two-year period following drug infusion, concordant with subsiding gut symptoms. These data demonstrate that TGN1412-induced gastrointestinal symptoms were associated with dysregulation of the ‘gut-homing’ pool of blood αβ and γδT11 cells, induced directly by the antibody and/or arising from the subsequent cytokine storm.
CitationMcCarthy, N.E., Stagg, A.J., Price, C.L. et al. (2021) Patients with gastrointestinal irritability after TGN1412-induced cytokine 2 storm displayed selective expansion of gut-homing αβ and γδ T-cells, Cancer Immunology Immunotherapy. 70, pp.1143–1153. https://doi.org/10.1007/s00262-020-02723-4
JournalCancer Immunology Immunotherapy
DescriptionThis is an accepted manuscript of an article published by Springer in Cancer Immunology, Immunotherapy on 13/10/2020, available online at: https://doi.org/10.1007/s00262-020-02723-4 The accepted version of the publication may differ from the final published version
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/