Decreased postural control in adult survivors of childhood cancer treated with chemotherapy
Authors
Einarsson, Einar-JónPatel, Mitesh
Petersen, Hannes
Wiebe, Thomas
Fransson, Per-Anders
Magnusson, Måns
Moëll, Christian
Issue Date
2016-11-10
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The objective of cancer treatment is to secure survival. However, as chemotherapeutic agents can affect the central and peripheral nervous systems, patients must undergo a process of central compensation. We explored the effectiveness of this compensation process by measuring postural behaviour in adult survivors of childhood cancer treated with chemotherapy (CTS). We recruited sixteen adults treated with chemotherapy in childhood for malignant solid (non-CNS) tumours and 25 healthy age-matched controls. Subjects performed posturography with eyes open and closed during quiet and perturbed standing. Repeated balance perturbations through calf vibrations were used to study postural adaptation. Subjects were stratified into two groups (treatment before or from 12 years of age) to determine age at treatment effects. Both quiet (p = 0.040) and perturbed standing (p ≤ 0.009) were significantly poorer in CTS compared to controls, particularly with eyes open and among those treated younger. Moreover, CTS had reduced levels of adaptation compared to controls, both with eyes closed and open. Hence, adults treated with chemotherapy for childhood cancer may suffer late effects of poorer postural control manifested as reduced contribution of vision and as reduced adaptation skills. These findings advocate development of chemotherapeutic agents that cause fewer long-term side effects when used for treating children.Citation
Einarsson, E., Patel, M., Petersen, H., Wiebe, T., et al. (2016) Decreased postural control in adult survivors of childhood cancer treated with chemotherapy, Scientific Reports 6, 36784. DOI: 10.1038/srep36784Publisher
Springer Science and Business Media LLCJournal
Scientific ReportsAdditional Links
https://www.nature.com/articles/srep36784Type
Journal articleLanguage
enDescription
© 2016 The Authors. Published by Nature Research. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1038/srep36784ISSN
2045-2322EISSN
2045-2322Sponsors
The authors’ wish to acknowledge the financial supported from the Swedish Medical Research Council (grant nr. 17x-05693), the Medical Faculty, Lund University, Sweden and the Skåne County Council’s research and development foundation.ae974a485f413a2113503eed53cd6c53
10.1038/srep36784
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/