Effects of prochlorperazine on normal vestibular ocular and perceptual responses: a randomised, double-blind, crossover, placebo-controlled study
dc.contributor.author | Patel, Mitesh | |
dc.contributor.author | Nigmatullina, Y | |
dc.contributor.author | Seemungal, BM | |
dc.contributor.author | Golding, JF | |
dc.contributor.author | Bronstein, AM | |
dc.date.accessioned | 2020-08-04T11:42:33Z | |
dc.date.available | 2020-08-04T11:42:33Z | |
dc.date.issued | 2013-12-21 | |
dc.identifier.citation | Patel, M., Nigmatullina, Y., Seemungal, B. M., Golding, J. F., et al. (2014) Effects of prochlorperazine on normal vestibular ocular and perceptual responses: a randomised, double-blind, crossover, placebo-controlled study. Audiology and Neurotology, 19(2) pp.91-96. DOI: 10.1159/000357028 | en |
dc.identifier.issn | 1420-3030 | en |
dc.identifier.doi | 10.1159/000357028 | en |
dc.identifier.uri | http://hdl.handle.net/2436/623433 | |
dc.description | This is an accepted manuscript of an article published by Karger Publishers in Audiology and Neurotology on 21 December 2013, available online: https://doi.org/10.1159/000357028 The accepted version of the publication may differ from the final published version. | en |
dc.description.abstract | Background: The present study investigated whether prochlorperazine affects vestibulo-ocular reflex (VOR) and vestibulo-perceptual function. Methods: We studied 12 healthy naïve subjects 3 h after a single dose of oral prochlorperazine 5 mg in a randomised, placebo-controlled, double-blind, crossover study in healthy young subjects. Two rotational tests in yaw were used: (1) a threshold task investigating perceptual motion detection and nystagmic thresholds (acceleration steps of 0.5°/s2) and (2) suprathreshold responses to velocity steps of 90°/s in which vestibulo-ocular and vestibuloperceptual time constants of decay, as well as VOR gain, were measured. Results: Prochlorperazine had no effect upon any measure of nystagmic or perceptual vestibular function compared to placebo. This lack of effects on vestibular-mediated motion perception suggests that the drug is likely to act more as an anti-emetic than as an antivertiginous agent. | en |
dc.description.sponsorship | This work was generously supported by an MRC grant to A.M.B. (MC_U950770497). MP is funded by the Meniere’s Society, UK. | en |
dc.format | application/pdf | en |
dc.language | en | |
dc.language.iso | en | en |
dc.publisher | S. Karger AG | en |
dc.relation.url | https://www.karger.com/Article/Abstract/357028# | en |
dc.subject | vestibular | en |
dc.subject | velocity storage | en |
dc.subject | perception | en |
dc.subject | eye movement | en |
dc.subject | dizziness | en |
dc.title | Effects of prochlorperazine on normal vestibular ocular and perceptual responses: a randomised, double-blind, crossover, placebo-controlled study | en |
dc.type | Journal article | en |
dc.identifier.eissn | 1421-9700 | |
dc.identifier.journal | Audiology and Neurotology | en |
dc.date.updated | 2020-07-24T09:54:56Z | |
dc.date.accepted | 2013-10-30 | |
rioxxterms.funder | Medical Research Council, Meniere’s Society, UK. | en |
rioxxterms.identifier.project | MC_U950770497 | en |
rioxxterms.version | AM | en |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
rioxxterms.licenseref.startdate | 2020-08-04 | en |
dc.source.volume | 19 | |
dc.source.issue | 2 | |
dc.source.beginpage | 91 | |
dc.source.endpage | 96 | |
dc.description.version | Published version | |
refterms.dateFCD | 2020-08-04T11:41:19Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2020-08-04T00:00:00Z |