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dc.contributor.authorPatel, Mitesh
dc.contributor.authorNigmatullina, Y
dc.contributor.authorSeemungal, BM
dc.contributor.authorGolding, JF
dc.contributor.authorBronstein, AM
dc.date.accessioned2020-08-04T11:42:33Z
dc.date.available2020-08-04T11:42:33Z
dc.date.issued2013-12-21
dc.identifier.citationPatel, M., Nigmatullina, Y., Seemungal, B. M., Golding, J. F., et al. (2014) Effects of prochlorperazine on normal vestibular ocular and perceptual responses: a randomised, double-blind, crossover, placebo-controlled study. Audiology and Neurotology, 19(2) pp.91-96. DOI: 10.1159/000357028en
dc.identifier.issn1420-3030en
dc.identifier.doi10.1159/000357028en
dc.identifier.urihttp://hdl.handle.net/2436/623433
dc.descriptionThis is an accepted manuscript of an article published by Karger Publishers in Audiology and Neurotology on 21 December 2013, available online: https://doi.org/10.1159/000357028 The accepted version of the publication may differ from the final published version.en
dc.description.abstractBackground: The present study investigated whether prochlorperazine affects vestibulo-ocular reflex (VOR) and vestibulo-perceptual function. Methods: We studied 12 healthy naïve subjects 3 h after a single dose of oral prochlorperazine 5 mg in a randomised, placebo-controlled, double-blind, crossover study in healthy young subjects. Two rotational tests in yaw were used: (1) a threshold task investigating perceptual motion detection and nystagmic thresholds (acceleration steps of 0.5°/s2) and (2) suprathreshold responses to velocity steps of 90°/s in which vestibulo-ocular and vestibuloperceptual time constants of decay, as well as VOR gain, were measured. Results: Prochlorperazine had no effect upon any measure of nystagmic or perceptual vestibular function compared to placebo. This lack of effects on vestibular-mediated motion perception suggests that the drug is likely to act more as an anti-emetic than as an antivertiginous agent.en
dc.description.sponsorshipThis work was generously supported by an MRC grant to A.M.B. (MC_U950770497). MP is funded by the Meniere’s Society, UK.en
dc.formatapplication/pdfen
dc.languageen
dc.language.isoenen
dc.publisherS. Karger AGen
dc.relation.urlhttps://www.karger.com/Article/Abstract/357028#en
dc.subjectvestibularen
dc.subjectvelocity storageen
dc.subjectperceptionen
dc.subjecteye movementen
dc.subjectdizzinessen
dc.titleEffects of prochlorperazine on normal vestibular ocular and perceptual responses: a randomised, double-blind, crossover, placebo-controlled studyen
dc.typeJournal articleen
dc.identifier.eissn1421-9700
dc.identifier.journalAudiology and Neurotologyen
dc.date.updated2020-07-24T09:54:56Z
dc.date.accepted2013-10-30
rioxxterms.funderMedical Research Council, Meniere’s Society, UK.en
rioxxterms.identifier.projectMC_U950770497en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2020-08-04en
dc.source.volume19
dc.source.issue2
dc.source.beginpage91
dc.source.endpage96
dc.description.versionPublished version
refterms.dateFCD2020-08-04T11:41:19Z
refterms.versionFCDAM
refterms.dateFOA2020-08-04T00:00:00Z


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