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dc.contributor.authorAgbuduwe, Charles
dc.contributor.authorBasu, Supratik
dc.date.accessioned2020-08-03T08:22:28Z
dc.date.available2020-08-03T08:22:28Z
dc.date.issued2020-07-14
dc.identifier.citationAgbuduwe, C. and Basu, S. (2020), Hematolological manifestations of COVID‐19: From cytopenia to coagulopathy. European Journal of Haematology 105, pp. 540– 546. https://doi.org/10.1111/ejh.13491.en
dc.identifier.issn0902-4441en
dc.identifier.doi10.1111/ejh.13491en
dc.identifier.urihttp://hdl.handle.net/2436/623410
dc.descriptionThis is an accepted manuscript of an article published by Wiley in European Journal of Haematology on 14/07/2020, available online: https://doi.org/10.1111/ejh.13491 The accepted version of the publication may differ from the final published version.en
dc.description.abstractEmerging data from the management of patients with Coronavirus Disease 2019 (COVID‐19) suggests multisystemic involvement, including the hemopoietic system. The hematological manifestations of COVID‐19 include blood count anomalies notably lymphopenia and neutrophilia which are of prognostic significance. Hyperferritinemia and elevated lactate dehydrogenase have also been associated with increased mortality. Furthermore, there is considerable evidence of a distinct coagulopathy associated with COVID‐19 characterised by elevated D‐dimers and an increased risk of thrombotic events. This comprehensive review summarises the latest evidence from published studies and discusses the implications of the various hematological manifestations of COVID‐19 with a view to guiding clinical management and risk stratification in this rapidly evolving pandemic.en
dc.description.sponsorshipCA is a recipient of a clinical research fellowship funded by the CRUK-City of London Centre Clinical Academic Training Programme Award [C355/A28852]en
dc.formatapplication/pdfen
dc.languageenglish
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1111/ejh.13491en
dc.subjectimmunologyen
dc.subjectinfectious diseaseen
dc.subjecthaematologyen
dc.subjecthaematopathologyen
dc.subjectblood counten
dc.subjectcoagulopathyen
dc.subjectCOVID-19en
dc.subjectcytokine stormen
dc.subjectD-dimeren
dc.subjectlymphopeniaen
dc.subjectSARS-CoV-2en
dc.titleHematolological manifestations of COVID-19: From cytopenia to coagulopathyen
dc.typeJournal articleen
dc.identifier.journalEuropean Journal of Haematologyen
dc.date.updated2020-07-14T11:28:19Z
dc.date.accepted2020-07-09
rioxxterms.funderCancer Research UKen
rioxxterms.identifier.projectC355/A28852en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2021-07-14en
dc.source.volume105
dc.source.issue5
dc.source.beginpage540
dc.source.endpage546
refterms.dateFCD2020-08-03T08:19:36Z
refterms.versionFCDAM
refterms.dateFOA2021-07-14T00:00:00Z


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