Association of air pollution with the risk of initial outpatient visits for tuberculosis in Wuhan, China
Authors
Xu, ManLao, Jiaqiang
Yin, Ping
Hou, Jiang
Zhou, Yun
Huang, Jiao
Liu, Bing
Chen, Ruoling
Ke, Li
Chen, Hongying
Hu, Ping
Issue Date
2019-07-12
Metadata
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© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. Objectives Previous studies suggested the association of air pollution with initial Mycobacterium tuberculosis infection and the disease development. However, few studies have been conducted on air pollution and initial tuberculosis (TB) consults using short-interval data. We investigated the weekly association between air pollution and initial TB outpatient visits. Methods We used a Poisson regression model combined with a distributed lag non-linear model to conduct a time-series study with weekly air pollution data and TB cases during 2014-2017 in Wuhan, China. Results A 10 μg/m 3 increase in NO 2 (nitrogen dioxide) was associated with 11.74% (95% CI: 0.70 to 23.98, lag 0-1 weeks), 21.45% (95% CI: 1.44 to 45.41, lag 0-2 weeks) and 12.8% (95% CI: 0.97 to 26.02, lag 0-1 weeks) increase in initial TB consults among all patients with TB, old patients (≥60 years old) and male ones, respectively. A 10 μg/m 3 increase in SO 2 (sulfur dioxide) was associated with -22.23% (95% CI: -39.23 to -0.49, lag 0-16 weeks), -28.65% (95% CI: -44.3 to -8.58, lag 0-16 weeks), -23.85 (95% CI: -41.79 to -0.37, lag 0-8 weeks) and -23.82% (95% CI: -41.31 to -1.11, lag 0-16 weeks) increase in initial TB consults among the total, young (aged 15-59 years old), old and male patients, respectively. In old patients, a 0.1 mg/m 3 increase in CO (carbon monoxide) and a 10 μg/m 3 increase in PM 2.5 (particulate matter) were separately associated with 42.32% (95% CI: 1.16 to 100.22, lag 0-16 weeks) and 17.38% (95% CI: 0.28 to 37.38, lag 0-16 weeks) increases in TB consults. Conclusion Our study first highlighted the importance of weekly association between air pollution and the risk of initial TB consults, which is helpful for the arrangements of TB screening and medical assistance.Citation
Xu, M., Liao, J., Yin, P., Hou, J. et al (2019) Association of air pollution with the risk of initial outpatient visits for tuberculosis in Wuhan, China, Occupational and Environmental Medicine, 76(8), pp.560-566.Publisher
BMJJournal
Occupational and Environmental MedicinePubMed ID
31300562 (pubmed)Additional Links
https://oem.bmj.com/content/76/8/560Type
Journal articleLanguage
enDescription
This is an accepted manuscript of an article published by BMJ Publishing Group in Occupational and Environmental Medicine on 12//07/2019, available online: https://doi.org/10.1136/oemed-2018-105532 The accepted version of the publication may differ from the final published version.ISSN
1351-0711EISSN
1470-7926Sponsors
The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.ae974a485f413a2113503eed53cd6c53
10.1136/oemed-2018-105532
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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc/4.0/
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