Influence of periodontal disease on risk of dementia: a systematic literature review and a meta-analysis
Authors
Nadim, RizwanTang, Jie
Dilmohamed, A
Yuan, S
Wu, C
Bakre, Aishat
Partridge, Martin
Ni, Jindong
Copeland, John R
Anstey, Kaarin J.
Chen, Ruoling
Issue Date
2020-06-12
Metadata
Show full item recordAbstract
Periodontal disease (PD) is common and increases cardiovascular diseases. However, it is unclear whether PD is associated with increased risk of dementia. We carried out a systematic review and meta-analysis to investigate the influence of PD on dementia. We projected the number of dementia cases to be saved by reducing PD prevalence in the world. We searched cohort and case–control studies reporting the association of PD with all dementia (or any specific type of dementia) through PubMed, MEDLINE, PsycINFO, SocINDEX, CINHAL, and CNKI until 7th November 2018. Five cohorts and seven case–control studies were identified for review. We pooled eligible data to calculate relative risk (RR) of dementia in relation to PD and computed the number of dementia cases saved through reducing PD prevalence. Of 12 studies, six were undertaken in Asia, four in Europe and two in America. Eleven studies showed a positive association between PD and the risk of dementia, of which 10 were significant, and one reported a non-significant inverse association. Overall their quality was good. Pooled RR of dementia in relation to PD from all high quality studies was 1.38 (95%CI 1.01–1.90); in the five cohorts was 1.18 (1.06–1.31) and in the two case–control studies 2.25 (1.48–3.42). A 50% reduction in the current prevalence of 20% of PD in the population could save 850,000 (630,000–1,420,000) patients with dementia in the world. PD could increase the risk of incident dementia. Preventing and treating PD could contribute to controlling the global epidemic of dementia.Citation
Nadim, R., Tang, J., Dilmohamed, A. et al. (2020) Influence of periodontal disease on risk of dementia: a systematic literature review and a meta-analysis. European Journal of Epidemiology. https://doi.org/10.1007/s10654-020-00648-xPublisher
Springer Science and Business Media LLCJournal
European Journal of EpidemiologyPubMed ID
32533373 (pubmed)Additional Links
https://link.springer.com/article/10.1007%2Fs10654-020-00648-xType
Journal articleLanguage
enDescription
This is an accepted manuscript of an article published by Springer in European Journal of Epidemiology on 12/06/2020, available online: https://doi.org/10.1007/s10654-020-00648-x The accepted version of the publication may differ from the final published version.ISSN
0393-2990EISSN
1573-7284Sponsors
Professor Ruoling Chen and Dr Jie Tang thank an EU Grant from Horizon 2020 MSCA – DEMAIRPO #799247. Dr Kaarin Anstey is funded by NHMRC Fellowship #1102694. Dr Wu is the recipient of BBSRC [BB/P004695/1] and NIA [1R01AG049321-01A1] Grant for aging research. Dr Yuyou Yao, Associate Professor of Anhui Medical University, China is a visiting scholar at the Faculty of Education, Health and Wellbeing, University of Wolverhampton to support this study and has made valuable comments on the manuscript.ae974a485f413a2113503eed53cd6c53
10.1007/s10654-020-00648-x
Scopus Count
Collections
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/
Related articles
- Influence of periodontal disease on risk of dementia: a systematic literature review and a meta-analysis.
- Authors: Nadim R, Tang J, Dilmohamed A, Yuan S, Wu C, Bakre AT, Partridge M, Ni J, Copeland JR, Anstey KJ, Chen R
- Issue date: 2020 Sep
- The impact of study factors in the association of periodontal disease and cognitive disorders: systematic review and meta-analysis.
- Authors: Larvin H, Gao C, Kang J, Aggarwal VR, Pavitt S, Wu J
- Issue date: 2023 Feb 1
- Is Periodontal Disease Associated with Alzheimer's Disease? A Systematic Review with Meta-Analysis.
- Authors: Leira Y, Domínguez C, Seoane J, Seoane-Romero J, Pías-Peleteiro JM, Takkouche B, Blanco J, Aldrey JM
- Issue date: 2017
- Periodontal disease severity in subjects with dementia: A systematic review and meta-analysis.
- Authors: Gusman DJR, Mello-Neto JM, Alves BES, Matheus HR, Ervolino E, Theodoro LH, de Almeida JM
- Issue date: 2018 May-Jun