The role of WNT signalling in chronic kidney disease (CKD)

Malik, SA; Modarage, K; Goggolidou, P

dc.contributor.author	Malik, SA
dc.contributor.author	Modarage, K
dc.contributor.author	Goggolidou, P
dc.date.accessioned	2020-07-21T12:59:05Z
dc.date.available	2020-07-21T12:59:05Z
dc.date.issued	2020-04-30
dc.identifier.citation	Malik, S.A., Modarage, K. and Goggolidou, P. (2020) The Role of Wnt Signalling in Chronic Kidney Disease (CKD). Genes, 11(5), 496. https://doi.org/10.3390/genes11050496	en
dc.identifier.issn	2073-4425	en
dc.identifier.pmid	32365994 (pubmed)
dc.identifier.doi	10.3390/genes11050496	en
dc.identifier.uri	http://hdl.handle.net/2436/623375
dc.description	© 2020 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/genes11050496	en
dc.description.abstract	© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Chronic kidney disease (CKD) encompasses a group of diverse diseases that are associated with accumulating kidney damage and a decline in glomerular filtration rate (GFR). These conditions can be of an acquired or genetic nature and, in many cases, interactions between genetics and the environment also play a role in disease manifestation and severity. In this review, we focus on genetically inherited chronic kidney diseases and dissect the links between canonical and non-canonical Wnt signalling, and this umbrella of conditions that result in kidney damage. Most of the current evidence on the role of Wnt signalling in CKD is gathered from studies in polycystic kidney disease (PKD) and nephronophthisis (NPHP) and reveals the involvement of beta-catenin. Nevertheless, recent findings have also linked planar cell polarity (PCP) signalling to CKD, with further studies being required to fully understand the links and molecular mechanisms.	en
dc.format	application/pdf	en
dc.language	eng
dc.language.iso	en	en
dc.publisher	MDPI	en
dc.relation.url	https://www.mdpi.com/2073-4425/11/5/496	en
dc.subject	Wnt signalling	en
dc.subject	beta-catenin	en
dc.subject	nephronophthisis	en
dc.subject	planar cell polarity signalling	en
dc.subject	polycystic kidney disease	en
dc.title	The role of WNT signalling in chronic kidney disease (CKD)	en
dc.type	Journal article	en
dc.identifier.eissn	2073-4425
dc.identifier.journal	Genes	en
dc.date.updated	2020-07-01T07:55:46Z
dc.contributor.institution	Department of Biomedical Science and Physiology, Faculty of Science and Engineering, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1LY, UK.
pubs.place-of-publication	Switzerland
dc.date.accepted	2020-04-29
rioxxterms.funder	PKD Charity UK	en
rioxxterms.identifier.project	PKDC/ARPKD-1/2015	en
rioxxterms.version	VoR	en
rioxxterms.licenseref.uri	https://creativecommons.org/licenses/by/4.0/	en
rioxxterms.licenseref.startdate	2020-07-21	en
dc.source.volume	11
dc.source.issue	5
dc.source.beginpage	496
dc.source.endpage	496
dc.description.version	Published version
refterms.dateFCD	2020-07-21T12:58:54Z
refterms.versionFCD	VoR
refterms.dateFOA	2020-07-21T12:59:07Z