A mechanistic role for leptin in human dendritic cell migration: Differences between ileum and colon in health and Crohn's disease
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Authors
Al-Hassi, HOBernardo, D
Murugananthan, AU
Mann, ER
English, NR
Jones, A
Kamm, MA
Arebi, N
Hart, AL
Blakemore, AIF
Stagg, AJ
Knight, SC
Issue Date
2012-11-21
Metadata
Show full item recordAbstract
Dendritic cells (DC) migrate to lymph nodes on expression of C-C motif chemokine receptor 7 (CCR7) and control immune activity. Leptin, an immunomodulatory adipokine, functions via leptin receptors, signaling via the long isoform of receptor, LepRb. Leptin promotes DC maturation and increases CCR7 expression on blood DC. Increased mesenteric fat and leptin occur early in Crohn's disease (CD), suggesting leptin-mediated change in intestinal CCR7 expression on DC as a pro-inflammatory mechanism. We have demonstrated CCR7 expression and capacity to migrate to its ligand macrophage inflammatory protein 3β in normal human ileal DC but not colonic or blood DC. In CD, functional CCR7 was expressed on DC from all sites. Only DC populations containing CCR7-expressing cells produced LepRb; in vitro exposure to leptin also increased expression of functional CCR7 in intestinal DC in a dose-dependent manner. In conclusion, leptin may regulate DC migration from gut, in homeostatic and inflammatory conditions, providing a link between mesenteric obesity and inflammation. © 2013 Society for Mucosal Immunology.Citation
Al-Hassi, H., Bernardo, D., Murugananthan, A. et al. (2013) A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn’s disease. Mucosal Immunol 6, pp. 751–761. https://doi.org/10.1038/mi.2012.113Publisher
Springer Science and Business Media LLCJournal
Mucosal ImmunologyPubMed ID
23168838 (pubmed)Additional Links
https://www.nature.com/articles/mi2012113Type
Journal articleLanguage
enDescription
© 2012 The Authors. Published by Springer Nature. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1038/mi.2012.113ISSN
1933-0219EISSN
1935-3456Sponsors
We thank The Broad Medical Research Program of the Broad Foundation, USA, the Medical Research Council Trust, UK, St Mark’s Hospital Foundation, UK, the Biotechnology and Biological Research Council Institute Strategic Program for Gut Health and Food Safety BB/J004529/1 and the Brigid Balfour Fund for funding this study. A.I.F.B. is also funded by Diabetes UK and the BRC at the Imperial College Healthcare Trust.ae974a485f413a2113503eed53cd6c53
10.1038/mi.2012.113
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Except where otherwise noted, this item's license is described as Licence for published version: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
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