Ulcerative colitis: Understanding its cellular pathology could provide insights into novel therapies
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
Abstract© 2020 The Author(s). Dynamic interactions between the gastrointestinal epithelium and the mucosal immune system normally contribute to ensuring intestinal homeostasis and optimal immunosurveillance, but destabilisation of these interactions in genetically predisposed individuals can lead to the development of chronic inflammatory diseases. Ulcerative colitis is one of the main types of inflammatory diseases that affect the bowel, but its pathogenesis has yet to be completely defined. Several genetic factors and other inflammation-related genes are implicated in mediating the inflammation and development of the disease. Some susceptibility loci associated with increased risk of ulcerative colitis are found to be implicated in mucosal barrier function. Different biomarkers that cause damage to the colonic mucosa can be detected in patients, including perinuclear ANCA, which is also useful in distinguishing ulcerative colitis from other colitides. The choice of treatment for ulcerative colitis depends on disease severity. Therapeutic strategies include anti-tumour necrosis factor alpha (TNF-α) monoclonal antibodies used to block the production of TNF-α that mediates intestinal tract inflammation, an anti-adhesion drug that prevents lymphocyte infiltration from the blood into the inflamed gut, inhibitors of JAK1 and JAK3 that suppress the innate immune cell signalling and interferons α/β which stimulate the production of anti-inflammatory cytokines, as well as faecal microbiota transplantation. Although further research is still required to fully dissect the pathophysiology of ulcerative colitis, understanding its cellular pathology and molecular mechanisms has already proven beneficial and it has got the potential to identify further novel, effective targets for therapy and reduce the burden of this chronic disease.
CitationKaur, A. and Goggolidou, P. (2020) Ulcerative colitis: Understanding its cellular pathology could provide insights into novel therapies, Journal of Inflammation, 17, 15 (2020). https://doi.org/10.1186/s12950-020-00246-4
PublisherSpringer Science and Business Media LLC
JournalJournal of Inflammation
PubMed ID32336953 (pubmed)
Description© 2020 The Authors. Published by BMC part of Springer Nature. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1186/s12950-020-00246-4
Except where otherwise noted, this item's license is described as Licence for published version: Creative Commons Attribution 4.0 International
- Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies.
- Authors: Kaur A, Goggolidou P
- Issue date: 2020
- Development, validation and implementation of an in vitro model for the study of metabolic and immune function in normal and inflamed human colonic epithelium.
- Authors: Pedersen G
- Issue date: 2015 Jan
- Genetic heterogeneity within ulcerative colitis determined by an interleukin-1 receptor antagonist gene polymorphism and antineutrophil cytoplasmic antibodies.
- Authors: Papo M, Quer JC, Gutierrez C, Broch M, Casellas F, Pastor RM, Olona M, Richart C
- Issue date: 1999 Apr
- KFL2 participates in the development of ulcerative colitis through inhibiting inflammation via regulating cytokines.
- Authors: Wang ZL, Wang YD, Wang K, Li JA, Li L
- Issue date: 2018 Aug