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dc.contributor.authorSoo, BP
dc.contributor.authorRajbhandari, S
dc.contributor.authorEgun, A
dc.contributor.authorRanasinghe, U
dc.contributor.authorLahart, IM
dc.contributor.authorPappachan, JM
dc.date.accessioned2020-07-03T08:24:51Z
dc.date.available2020-07-03T08:24:51Z
dc.date.issued2020-04-12
dc.identifier.citationSoo, B.P., Rajbhandari, S., Egun, A., Ranasinghe, U., Lahart, I.M. and Pappachan, J.M. (2020) Survival at 10 years following lower extremity amputations in patients with diabetic foot disease, Endocrine (2020). https://doi.org/10.1007/s12020-020-02292-7en
dc.identifier.issn1355-008Xen
dc.identifier.pmid32281048 (pubmed)
dc.identifier.doi10.1007/s12020-020-02292-7en
dc.identifier.urihttp://hdl.handle.net/2436/623316
dc.descriptionThis is an accepted manuscript of an article published by Springer in Endocrine on 12/04/2020, available online: https://doi.org/10.1007/s12020-020-02292-7 The accepted version of the publication may differ from the final published version.en
dc.description.abstract© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Background: Amputations are associated with markedly reduced long-term survival in patients with diabetic foot disease. However, there is paucity of long-term survival data in published literature. Methods: We searched the electronic case records and laboratory details of patients who underwent amputations between 1997 and 2006 to obtain at least 10 years of follow up data after the surgery to assess the survival rates and possible risk factors reducing survival in the year 2016. Amputation level below ankle was considered as minor and above ankle as major amputations. Results: Of the 233 cases (159 males; median age 68 years), 161 had major amputations. Of the 72 cases who had minor amputations initially, 63 needed a further amputation or contralateral amputation on follow up. One hundred seventy-seven patients (76%) were not alive after 10 years of follow up. The survival rates at 1, 3, 5, 7, and ≥10 years were 64%, 50%, 40%, 34%, and 24%, respectively. Maximum number of deaths occurred within 4 months of amputations. There was no difference between survival rates following major or minor amputations and among males or females. The only statistically significant parameter affecting lower survival rate was age ≥70 years, with each additional year of age increasing the hazard by a factor of 1.039 (95% CI: 1.024–1.054) or 3.9% (2.4–5.4%). Conclusions: Five-year and 10-year survival rates were 40% and 24%, respectively, following diabetic foot amputations. Higher age ≥70 years was associated with lower survival rate compared with younger age groups after lower extremity amputations.en
dc.formatapplication/pdfen
dc.languageeng
dc.language.isoenen
dc.publisherSpringer Science and Business Media LLCen
dc.relation.urlhttps://link.springer.com/article/10.1007/s12020-020-02292-7en
dc.subjectdiabetic foot ulceren
dc.subjectlower extremity amputationsen
dc.subjectsurvival rateen
dc.titleSurvival at 10 years following lower extremity amputations in patients with diabetic foot diseaseen
dc.typeJournal articleen
dc.identifier.eissn1559-0100
dc.identifier.journalEndocrineen
dc.date.updated2020-07-01T22:30:54Z
dc.contributor.institutionDepartment of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Foundation Trust, Lancashire, UK.
pubs.place-of-publicationUnited States
dc.date.accepted2020-03-27
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW03072020ILen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2021-04-12en
dc.description.versionPublished version
refterms.dateFCD2020-07-03T08:23:27Z
refterms.versionFCDAM


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