Abstract© 2020 Based on current knowledge deriving from studies in animals and humans (the general population and patients with non-communicable diseases), there is biological plausibility that exercise may have anti-inflammatory effects. This may be particularly important for patients with chronic inflammatory rheumatic and musculoskeletal diseases (RMDs). The present review discusses the current state-of-the-art on exercise and inflammation, explores how exercise can moderate inflammation-dependent RMD outcomes and the most prevalent systemic manifestations and addresses the relationship between the dosage (particularly the intensity) of exercise and inflammation. We conclude that present data support potential beneficial effects of exercise on inflammation, however, the evidence specifically in RMDs is limited and inconclusive. More targeted research is required to elucidate the effects of exercise on inflammation in the context of RMDs.
CitationMetsios, G.S., Moe, R.H. and Kitas, G.D. (2020) Exercise and inflammation, Best Practice and Research: Clinical Rheumatology. https://doi.org/10.1016/j.berh.2020.101504
JournalBest Practice and Research: Clinical Rheumatology
DescriptionThis is an accepted manuscript of an article published by Elsevier in Best Practice and Research: Clinical Rheumatology on 02/04/2020, available online: https://doi.org/10.1016/j.berh.2020.101504 The accepted version of the publication may differ from the final published version.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/