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dc.contributor.authorArshad, Qadeer
dc.contributor.authorSiddiqui, S.
dc.contributor.authorRamachandran, S.
dc.contributor.authorGoga, U.
dc.contributor.authorBonsu, A.
dc.contributor.authorPatel, Mitesh
dc.contributor.authorRoberts, R. E.
dc.contributor.authorNigmatullina, Y.
dc.contributor.authorMalhotra, P.
dc.contributor.authorBronstein, Adolfo M.
dc.date.accessioned2020-06-15T14:34:30Z
dc.date.available2020-06-15T14:34:30Z
dc.date.issued2015-10-27
dc.identifier.citationArshad, Q., Siddiqui, S., Ramachandran, S., Goga, U., Bonsu, A., Patel, M., Roberts, R.E., Nigmatullina, Y., Malhotra, P. and Bronstein, A.M. (2015) Right hemisphere dominance directly predicts both baseline V1 cortical excitability and the degree of top-down modulation exerted over low-level brain structures, Neuroscience, 311(December 2015), pp. 484-489.en
dc.identifier.issn0306-4522en
dc.identifier.doi10.1016/j.neuroscience.2015.10.045en
dc.identifier.urihttp://hdl.handle.net/2436/623259
dc.description© 2015 The Authors. Published by Elsevier. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1016/j.neuroscience.2015.10.045en
dc.description.abstractRight hemisphere dominance for visuo-spatial attention is characteristically observed in most right-handed individuals. This dominance has been attributed to both an anatomically larger right fronto-parietal network and the existence of asymmetric parietal interhemispheric connections. Previously it has been demonstrated that interhemispheric conflict, which induces left hemisphere inhibition, results in the modulation of both (i) the excitability of the early visual cortex (V1) and (ii) the brainstem-mediated vestibular–ocular reflex (VOR) via top-down control mechanisms. However to date, it remains unknown whether the degree of an individual’s right hemisphere dominance for visuospatial function can influence, (i) the baseline excitability of the visual cortex and (ii) the extent to which the right hemisphere can exert top-down modulation. We directly tested this by correlating line bisection error (or pseudoneglect), taken as a measure of right hemisphere dominance, with both (i) visual cortical excitability measured using phosphene perception elicited via single-pulse occipital trans-cranial magnetic stimulation (TMS) and (ii) the degree of trans-cranial direct current stimulation (tDCS)-mediated VOR suppression, following left hemisphere inhibition. We found that those individuals with greater right hemisphere dominance had a less excitable early visual cortex at baseline and demonstrated a greater degree of vestibular nystagmus suppression following left hemisphere cathodal tDCS. To conclude, our results provide the first demonstration that individual differences in right hemisphere dominance can directly predict both the baseline excitability of low-level brain structures and the degree of top-down modulation exerted over them.en
dc.formatapplication/pdfen
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0306452215009641?via%3Dihuben
dc.subjectright hemisphere dominanceen
dc.subjectvisual cortical excitabilityen
dc.subjectvestibular–ocular reflexen
dc.subjectline bisectionen
dc.subjecttop-down modulationen
dc.titleRight hemisphere dominance directly predicts both baseline V1 cortical excitability and the degree of top-down modulation exerted over low-level brain structuresen
dc.typeJournal articleen
dc.identifier.journalNeuroscienceen
dc.date.accepted2015-10-23
rioxxterms.funderImperial Collegeen
rioxxterms.identifier.projectUOW15062020MPPen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2020-06-15en
dc.source.volume311
dc.source.beginpage484
dc.source.endpage489
refterms.dateFCD2020-06-15T14:32:33Z
refterms.versionFCDVoR
refterms.dateFOA2020-06-15T14:34:32Z


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