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dc.contributor.authorKeyler, Daniel E
dc.contributor.authorSaini, Vinay
dc.contributor.authorO'Shea, Mark
dc.contributor.authorGee, Jeff
dc.contributor.authorSmith, Cara F
dc.contributor.authorMackessy, Stephen P
dc.date.accessioned2020-04-09T09:39:39Z
dc.date.available2020-04-09T09:39:39Z
dc.date.issued2020-03-12
dc.identifier.citationKeyler, D.E., Saini, V., O'Shea, M., Gee, J., Smith, C.F. and Mackessy, S.P. (2020) Crotalus oreganus concolor: Envenomation Case with Venom Analysis and a Diagnostic Conundrum of Myoneurologic Symptoms, Wilderness & Environmental Medicine (in press). DOI: https://doi.org/10.1016/j.wem.2019.12.007en
dc.identifier.issn1080-6032en
dc.identifier.pmid32173212
dc.identifier.doi10.1016/j.wem.2019.12.007en
dc.identifier.urihttp://hdl.handle.net/2436/623177
dc.descriptionThis is an accepted manuscript of an article published by Elsevier in Wilderness & Environmental Medicine on 12/03/2020, available online: https://doi.org/10.1016/j.wem.2019.12.007 The accepted version of the publication may differ from the final published version.en
dc.description.abstractA case of midget-faded rattlesnake (Crotalus oreganus concolor) envenomation of an adult male professional herpetologist occurred in a rural setting and resulted in an array of venom induced myoneurologic symptoms. The patient experienced blurry vision, total body paresthesia, dyspnea, chest tightness, and waves of spastic muscle movements of the hands and feet that resembled tetany. It was not apparent whether these symptoms were potentially venom induced or were related to stress-induced physiologic responses. Local envenomation effects were minimal, and coagulation parameters remained within normal limits. Antivenom was not administered per patient concerns related to a history of acute allergic reactions to antivenom. Venom was collected from the Crotalus oreganus concolor responsible for the bite, and analysis revealed the presence of high levels of myotoxins (SR calcium pump antagonists) and concolor toxin, a presynaptic neurotoxin that can have myotoxic effects and cause respiratory paralysis; several serine proteinases associated with coagulopathies were also present in the venom profile.en
dc.formatapplication/pdfen
dc.languageeng
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://www.wemjournal.org/article/S1080-6032(20)30006-5/fulltexten
dc.subjectalkalemiaen
dc.subjectcarpopedalen
dc.subjecthyperventilationen
dc.subjecthypocalcemiaen
dc.subjectrattlesnakeen
dc.subjectsnakebiteen
dc.titleCrotalus oreganus concolor: Envenomation Case with Venom Analysis and a Diagnostic Conundrum of Myoneurologic Symptomsen
dc.typeJournal articleen
dc.identifier.eissn1545-1534
dc.identifier.journalWilderness & Environmental Medicineen
dc.date.updated2020-04-08T12:17:29Z
dc.contributor.institutionDepartment of Experimental & Clinical Pharmacology, University of Minnesota, Minneapolis, MN. Electronic address: keyle001@umn.edu.
pubs.place-of-publicationUnited States
dc.date.accepted2019-12-09
rioxxterms.funderEPSRCen
rioxxterms.identifier.projectUOW09042020MOen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2021-03-12en
dc.description.versionPublished version
refterms.dateFCD2020-04-09T09:38:45Z
refterms.versionFCDAM


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