Crotalus oreganus concolor: Envenomation Case with Venom Analysis and a Diagnostic Conundrum of Myoneurologic Symptoms
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractA case of midget-faded rattlesnake (Crotalus oreganus concolor) envenomation of an adult male professional herpetologist occurred in a rural setting and resulted in an array of venom induced myoneurologic symptoms. The patient experienced blurry vision, total body paresthesia, dyspnea, chest tightness, and waves of spastic muscle movements of the hands and feet that resembled tetany. It was not apparent whether these symptoms were potentially venom induced or were related to stress-induced physiologic responses. Local envenomation effects were minimal, and coagulation parameters remained within normal limits. Antivenom was not administered per patient concerns related to a history of acute allergic reactions to antivenom. Venom was collected from the Crotalus oreganus concolor responsible for the bite, and analysis revealed the presence of high levels of myotoxins (SR calcium pump antagonists) and concolor toxin, a presynaptic neurotoxin that can have myotoxic effects and cause respiratory paralysis; several serine proteinases associated with coagulopathies were also present in the venom profile.
CitationKeyler, D.E., Saini, V., O'Shea, M., Gee, J., Smith, C.F. and Mackessy, S.P. (2020) Crotalus oreganus concolor: Envenomation Case with Venom Analysis and a Diagnostic Conundrum of Myoneurologic Symptoms, Wilderness & Environmental Medicine (in press). DOI: https://doi.org/10.1016/j.wem.2019.12.007
JournalWilderness & Environmental Medicine
DescriptionThis is an accepted manuscript of an article published by Elsevier in Wilderness & Environmental Medicine on 12/03/2020, available online: https://doi.org/10.1016/j.wem.2019.12.007 The accepted version of the publication may differ from the final published version.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/
- Comparison of the protective effect of a commercially available western diamondback rattlesnake toxoid vaccine for dogs against envenomation of mice with western diamondback rattlesnake (Crotalus atrox), northern Pacific rattlesnake (Crotalus oreganus oreganus), and southern Pacific rattlesnake (Crotalus oreganus helleri) venom.
- Authors: Cates CC, Valore EV, Couto MA, Lawson GW, McCabe JG
- Issue date: 2015 Mar
- Intraspecific venom variation in the medically significant Southern Pacific Rattlesnake (Crotalus oreganus helleri): biodiscovery, clinical and evolutionary implications.
- Authors: Sunagar K, Undheim EA, Scheib H, Gren EC, Cochran C, Person CE, Koludarov I, Kelln W, Hayes WK, King GF, Antunes A, Fry BG
- Issue date: 2014 Mar 17
- Snake venomics of Crotalus tigris: the minimalist toxin arsenal of the deadliest Nearctic rattlesnake venom. Evolutionary Clues for generating a pan-specific antivenom against crotalid type II venoms [corrected].
- Authors: Calvete JJ, Pérez A, Lomonte B, Sánchez EE, Sanz L
- Issue date: 2012 Feb 3
- Crotalus durissus terrificus (viperidae; crotalinae) envenomation: Respiratory failure and treatment with antivipmyn TRI<sup>®</sup> antivenom.
- Authors: Baum RA, Bronner J, Akpunonu PDS, Plott J, Bailey AM, Keyler DE
- Issue date: 2019 May
- Canebrake rattlesnake envenomation.
- Authors: Carroll RR, Hall EL, Kitchens CS
- Issue date: 1997 Jul