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dc.contributor.authorMaley, MJ
dc.contributor.authorHouse, JR
dc.contributor.authorTipton, MJ
dc.contributor.authorEglin, CM
dc.date.accessioned2020-03-20T13:58:37Z
dc.date.available2020-03-20T13:58:37Z
dc.date.issued2015-08-25
dc.identifier.citationMaley, M.J., Jouse, J.R., Tipton, M.J. and Eglin, C.M. (2015) Vascular responses of the extremities to transdermal application of vasoactive agents in Caucasian and African descent individuals, European Journal of Applied Physiology, 115, pp. 1801–1811.en
dc.identifier.issn1439-6319en
dc.identifier.pmid25840674
dc.identifier.doi10.1007/s00421-015-3164-2en
dc.identifier.urihttp://hdl.handle.net/2436/623156
dc.descriptionThis is an accepted manuscript of an article published by Springer in European Journal of Applied Physiology on 04/04/2015, available online: https://doi.org/10.1007/s00421-015-3164-2 The accepted version of the publication may differ from the final published version.en
dc.description.abstract© 2015, Springer-Verlag Berlin Heidelberg. Purpose: Individuals of African descent (AFD) are more susceptible to non-freezing cold injury than Caucasians (CAU) which may be due, in part, to differences in the control of skin blood flow. We investigated the skin blood flow responses to transdermal application of vasoactive agents. Methods: Twenty-four young males (12 CAU and 12 AFD) undertook three tests in which iontophoresis was used to apply acetylcholine (ACh 1 w/v %), sodium nitroprusside (SNP 0.01 w/v %) and noradrenaline (NA 0.5 mM) to the skin. The skin sites tested were: volar forearm, non-glabrous finger and toe, and glabrous finger (pad) and toe (pad). Results: In response to SNP on the forearm, AFD had less vasodilatation for a given current application than CAU (P = 0.027–0.004). ACh evoked less vasodilatation in AFD for a given application current in the non-glabrous finger and toe compared with CAU (P = 0.043–0.014) with a lower maximum vasodilatation in the non-glabrous finger (median [interquartile], AFD n = 11, 41[234] %, CAU n = 12, 351[451] %, P = 0.011) and non-glabrous toe (median [interquartile], AFD n = 9, 116[318] %, CAU n = 12, 484[720] %, P = 0.018). ACh and SNP did not elicit vasodilatation in the glabrous skin sites of either group. There were no ethnic differences in response to NA. Conclusion: AFD have an attenuated endothelium-dependent vasodilatation in non-glabrous sites of the fingers and toes compared with CAU. This may contribute to lower skin temperature following cold exposure and the increased risk of cold injuries experienced by AFD.en
dc.formatapplication/pdfen
dc.languageeng
dc.language.isoenen
dc.publisherSpringer Science and Business Media LLCen
dc.relation.urlhttps://link.springer.com/article/10.1007%2Fs00421-015-3164-2en
dc.subjectEthnicityen
dc.subjectVasodilatationen
dc.subjectVasoconstrictionen
dc.subjectGlabrousen
dc.subjectNon-glabrousen
dc.titleVascular responses of the extremities to transdermal application of vasoactive agents in Caucasian and African descent individualsen
dc.typeJournal articleen
dc.identifier.eissn1439-6327
dc.identifier.journalEuropean Journal of Applied Physiologyen
dc.date.updated2020-03-18T18:59:24Z
dc.contributor.institutionExtreme Environments Laboratory, Department of Sport and Exercise Science, University of Portsmouth, Portsmouth, PO1 2ER, UK, matthew.maley@port.ac.uk.
pubs.place-of-publicationGermany
dc.date.accepted2015-03-24
rioxxterms.funderNational Key Research and Development Plan, and National Natural Science Foundation of Chinaen
rioxxterms.identifier.projectUOW20032020MMen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2020-03-20en
dc.source.volume115
dc.source.issue8
dc.source.beginpage1801
dc.source.endpage1811
dc.description.versionPublished version
refterms.dateFCD2020-03-20T13:57:47Z
refterms.versionFCDAM
refterms.dateFOA2020-03-20T13:58:38Z


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