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dc.contributor.authorPalframan, MJ
dc.contributor.authorAlharthy, RD
dc.contributor.authorPowalowska, PK
dc.contributor.authorHayes, CJ
dc.date.accessioned2020-02-03T15:16:13Z
dc.date.available2020-02-03T15:16:13Z
dc.date.issued2016-02-16
dc.identifier.citationPalframan, M. J., Alharthy, R. D., Powalowska, P. K. and Hayes, C. J. (2016) Synthesis of triazole-linked morpholino oligonucleotides via Cu<sup>I</sup> catalysed cycloaddition, Organic and Biomolecular Chemistry, 14, pp. 3112–3119.en
dc.identifier.issn1477-0520en
dc.identifier.pmid26905296
dc.identifier.doi10.1039/c6ob00007jen
dc.identifier.urihttp://hdl.handle.net/2436/623043
dc.description.abstract© The Royal Society of Chemistry 2016. Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TLMO modification gives higher Tm values than the corresponding TLDNA modification.en
dc.description.sponsorshipKing Abdulaziz University, Saudi Arabia (Scholarship to R. D. A.) and the BBSRC (DTP Scholarship for P. K. P.)en
dc.formatapplication/pdfen
dc.languageeng
dc.language.isoenen
dc.publisherRoyal Society of Chemistry (RSC)en
dc.relation.urlhttps://pubs.rsc.org/en/content/articlelanding/2016/OB/C6OB00007J#!divAbstracten
dc.rightsLicence for published version: Creative Commons Attribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectcopperen
dc.subjectTriazolesen
dc.subjectDNAen
dc.subjectBase Sequenceen
dc.subjectNucleic Acid Denaturationen
dc.subjectCatalysisen
dc.subjectMorpholinosen
dc.subjectSolid-Phase Synthesis Techniquesen
dc.subjectCycloaddition Reactionen
dc.titleSynthesis of triazole-linked morpholino oligonucleotides via Cu<sup>I</sup> catalysed cycloadditionen
dc.typeJournal articleen
dc.identifier.eissn1477-0539
dc.identifier.journalOrganic and Biomolecular Chemistryen
dc.date.updated2020-01-31T15:18:47Z
dc.contributor.institutionSchool of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. chris.hayes@nottingham.ac.uk.
pubs.place-of-publicationEngland
dc.date.accepted2016-02-16
rioxxterms.funderKing Abdulaziz University, Saudi Arabia and the BBSRCen
rioxxterms.identifier.project1270876en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2020-02-03en
dc.source.volume14
dc.source.issue11
dc.source.beginpage3112
dc.source.endpage3119
dc.description.versionPublished version
refterms.dateFCD2020-02-03T15:15:46Z
refterms.versionFCDVoR
refterms.dateFOA2020-02-03T15:16:14Z


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Licence for published version: Creative Commons Attribution 4.0 International
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