Authors
Morris, MarkEditors
Hesson, LukePritchard, Antonia
Issue Date
2019-09-01
Metadata
Show full item recordAbstract
Cytosine methylation is an important epigenetic signalling mechanism that regulates gene expression. The presence of 5-methylcytosine (5-mC) at promoters is associated with gene silencing. In this chapter, we will describe our current understanding of 1. The mechanisms and molecules involved in the addition, and maintenance, of methyl groups to cytosine bases (5-mC writers) 2. The mechanism by which these 5-mC modifications are read resulting in changes in gene expression 3. The molecules and mechanisms involved in removing methyl groups from cytosine bases (5-mC erasers)Citation
Morris, M. (2019) The DNA methylation machinery, in Hesson, L. B. and Pritchard, A. L. (eds.) Clinical epigenetics. Singapore: Springer Nature Singapore, pp. 47-64.Publisher
Springer Nature SingaporeAdditional Links
https://link.springer.com/chapter/10.1007/978-981-13-8958-0_2Type
Chapter in bookLanguage
enISBN
9789811389573ae974a485f413a2113503eed53cd6c53
10.1007/978-981-13-8958-0