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AbstractCytosine methylation is an important epigenetic signalling mechanism that regulates gene expression. The presence of 5-methylcytosine (5-mC) at promoters is associated with gene silencing. In this chapter, we will describe our current understanding of 1. The mechanisms and molecules involved in the addition, and maintenance, of methyl groups to cytosine bases (5-mC writers) 2. The mechanism by which these 5-mC modifications are read resulting in changes in gene expression 3. The molecules and mechanisms involved in removing methyl groups from cytosine bases (5-mC erasers)
CitationMorris, M. (2019) The DNA methylation machinery, in Hesson, L. B. and Pritchard, A. L. (eds.) Clinical epigenetics. Singapore: Springer Nature Singapore, pp. 47-64.
PublisherSpringer Nature Singapore
TypeChapter in book
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