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dc.contributor.authorGupta, Abhishek
dc.contributor.authorBriffa, Sophie M
dc.contributor.authorSwingler, Sam
dc.contributor.authorGibson, Hazel
dc.contributor.authorKannappan, Vinodh
dc.contributor.authorAdamus, Grazyna
dc.contributor.authorKowalczuk, Marek M
dc.contributor.authorMartin, Claire
dc.contributor.authorRadecka, Iza
dc.date.accessioned2020-01-29T11:50:05Z
dc.date.available2020-01-29T11:50:05Z
dc.date.issued2020-01-22
dc.identifier.citationGupta, A., Briffa, S. M., Swingler, S., Gibson, H., Kannappan, V., Adamus, G., Kowalczuk, M. M., Martin, C. and Radecka, I. (2020) Synthesis of silver nanoparticles using curcumin-cyclodextrins loaded into bacterial cellulose based hydrogels for wound dressing applications, Biomacromolecules, 21(5), pp. 1802–1811. https://doi.org/10.1021/acs.biomac.9b01724en
dc.identifier.issn1525-7797en
dc.identifier.doi10.1021/acs.biomac.9b01724en
dc.identifier.urihttp://hdl.handle.net/2436/623029
dc.descriptionThis is an accepted manuscript of an article published by ACS in Biomacromolecules on 22/01/2020, available online: https://doi.org/10.1021/acs.biomac.9b01724 The accepted version of the publication may differ from the final published version.
dc.description.abstractChronic wounds are often recalcitrant to treatment due to high microbial bioburden and the problem of microbial resistance. Silver is a broad spectrum natural antimicrobial agent with wide applications extending to proprietary wound dressings. Recently silver nanoparticles have attracted attention in wound management. In the current study, the green synthesis of nanoparticles was accomplished using a natural reducing agent, curcumin which is a natural polyphenolic compound, well known as a wound healing agent. The hydrophobicity of curcumin was overcome by its microencapsulation in cyclodextrins. This prediction study demonstrates the production, characterisation of silver nanoparticles using aqueous curcumin:hydroxypropyl-β-cyclodextrin complex and loading them into bacterial cellulose hydrogel with moist wound healing properties. These silver nanoparticle-loaded bacterial cellulose hydrogels were characterised for wound management applications. In addition to high cytocompatibility, these novel dressings exhibited antimicrobial activity against three representative wound infecting pathogenic microbes Staphylococcus aureus, Pseudomonas. aeruginosa and Candida auris.en
dc.formatapplication/pdfen
dc.languageen
dc.language.isoenen
dc.publisherAmerican Chemical Society (ACS)en
dc.relation.urlhttps://pubs.acs.org/doi/10.1021/acs.biomac.9b01724en
dc.subjectsilver nanoparticlesen
dc.subjectgreen chemistryen
dc.subjectantimicrobialen
dc.subjecthydrogel dressingen
dc.subjectbacterial celluloseen
dc.subjectcurcumin reduced silver nanoparticlesen
dc.titleSynthesis of silver nanoparticles using curcumin-cyclodextrins loaded into bacterial cellulose based hydrogels for wound dressing applicationsen
dc.typeJournal articleen
dc.identifier.eissn1526-4602
dc.identifier.journalBiomacromoleculesen
dc.date.updated2020-01-28T12:55:56Z
dc.date.accepted2020-01-22
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW29012020IRen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2021-01-22en
dc.source.volume21
dc.source.issue5
dc.source.beginpage1802
dc.source.endpage1811
dc.description.versionPublished online
refterms.dateFCD2020-01-29T11:45:47Z
refterms.versionFCDAM


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