Efficacy and safety of brexpiprazole in acute management of psychiatric disorders: a meta-analysis of randomized controlled trials
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AbstractBrexpiprazole is a new atypical antipsychotic for schizophrenia management and as adjunct in major depressive disorder (MDD). We searched randomized controlled-trials (RCT) to review brexpiprazole efficacy and tolerability in acute management of schizophrenia and MDD using PubMed, EUDRACT, ClinicalTrials.gov and Cochrane Central Register of Controlled-Trials. A meta-analysis was conducted using the identified 14 RCT to assess its efficacy using positive and negative syndrome scale (PANSS), clinical global impressions – severity of Illness (CGI-S), Personal and Social Performance scale (PSP), Montgomery–Åsberg Depression Rating Scale (MADRS), Sheehan Disability Scale (SDS) and Hamilton Depression Rating Scale (HDRS17). The mean difference (MD) comparing brexpiprazole and placebo were PANSS -4.48, CGI-S -0.23 and PSP 3.24 favoring brexpiprazole. Compared to aripiprazole and quetiapine, brexpiprazole showed similar efficacy. In MDD, brexpiprazole showed efficacy compared to placebo demonstrated by MADRS -1.25, SDS -0.37 and HDRS17 -1.28. Brexpiprazole was associated with side effects including akathisia RR=1.72; weight increase RR=2.74 and somnolence RR=1.87. Compared to 4mg, brexpiprazole 2mg was associated with less risk of akathisia and Somnolence. Brexpiprazole demonstrated significant improvements in schizophrenia and MDD and is well-tolerated; however, associated with akathisia and somnolence. These findings will guide psychiatrists and pharmacists in their clinical role for supporting psychiatric patients care.
CitationAntoun Reyad, A., Girgis, E. and Mishriky, R. (2020) Efficacy and safety of brexpiprazole in acute management of psychiatric disorders: a meta-analysis of randomized controlled trials, International Clinical Psychopharmacology, 35(3), pp. 119-128. doi: 10.1097/YIC.0000000000000308
PublisherWolters Kluwer Health
JournalInternational Clinical Psychopharmacology
DescriptionThis is an accepted manuscript of an article published by Wolters Kluwer in International Clinical Psychopharmacology on 01/05/2020, available online: https://www.ingentaconnect.com/content/wk/incps/2020/00000035/00000003/art00001;jsessionid=11okj7rqu47a4.x-ic-live-01 The accepted version of the publication may differ from the final published version.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc/4.0/