Aqueous bark extracts of terminalia arjuna stimulates insulin release, enhances insulin action and inhibits starch digestion and protein glycation in vitro
dc.contributor.author | Thompson, HAJ | |
dc.contributor.author | Ojo, Opeolu | |
dc.contributor.author | Flatt, PR | |
dc.contributor.author | Abdel-Wahab, Y | |
dc.date.accessioned | 2019-10-03T11:03:50Z | |
dc.date.available | 2019-10-03T11:03:50Z | |
dc.date.issued | 2014-01-20 | |
dc.identifier.citation | Thomson HAJ, Ojo OO, Flatt PR, Abdel-Wahab YHA. Aqueous Bark Extracts of Terminalia Arjuna Stimulates Insulin Release, Enhances Insulin Action and Inhibits Starch Digestion and Protein Glycation in Vitro. Austin J Endocrinol Diabetes. 2014, 1(1):6. | en |
dc.identifier.issn | 2381-9200 | en |
dc.identifier.uri | http://hdl.handle.net/2436/622769 | |
dc.description.abstract | Scientific evidence for the effects of Terminalia arjuna on diabetes mellitus is lacking. This study investigated the anti-diabetic efficacy and mode of action of the bark extract of Terminalia arjuna. Insulin-release from BRIN-BD11 cells was assessed in the absence or presence of T. arjuna extracts and modulators of insulin-secretion. Insulin concentration and intracellular calcium ([Ca2+]i) were measured by radioimmunoassay and FLEXstationTM respectively. Adipocyte glucose-uptake with 3T3-L1 fibroblasts, starch digestion with α–amylase and protein glycation were assessed in vitro. Terminalia arjuna extract stimulated insulin-release alone (p<0.001), in combination with known modulators but not without extracellular Ca2+. It increased intracellular calcium but had no effects on depolarised cells. Glucose-uptake was enhanced in the presence of T. arjuna (P< 0.001). At higher concentrations, the extract decreased starch digestion and inhibited protein glycation (p<0.001). Terminalia arjuna extract possesses antidiabetic potential and may provide new opportunities for the treatment of diabetes. | en |
dc.format | application/PDF | en |
dc.language.iso | en | en |
dc.publisher | Austin Publishing Group | en |
dc.relation.url | https://austinpublishinggroup.com/endocrinology-diabetes/fulltext/ajed-v1-id1001.php | en |
dc.subject | Diabetes | en |
dc.subject | T. arjuna | en |
dc.subject | Insulin | en |
dc.subject | glucose uptake | en |
dc.title | Aqueous bark extracts of terminalia arjuna stimulates insulin release, enhances insulin action and inhibits starch digestion and protein glycation in vitro | en |
dc.type | Journal article | en |
dc.identifier.journal | Austin Journal of Endocrinology and Diabetes | en |
dc.date.updated | 2019-09-20T01:55:11Z | |
dc.date.accepted | 2014-01-17 | |
rioxxterms.funder | Jisc | en |
rioxxterms.identifier.project | UOW03102019OO | en |
rioxxterms.version | VoR | en |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0/ | en |
rioxxterms.licenseref.startdate | 2019-10-03 | en |
refterms.dateFCD | 2019-10-03T11:03:38Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2019-10-03T11:03:50Z |