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dc.contributor.authorHannan, J
dc.contributor.authorOjo, Opeolu
dc.contributor.authorRokeya, L
dc.contributor.authorKhaleque, J
dc.contributor.authorAkhter, M
dc.contributor.authorFlatt, P
dc.contributor.authorAbdel-Wahab, Y
dc.date.accessioned2019-10-03T10:46:31Z
dc.date.available2019-10-03T10:46:31Z
dc.date.issued2014-09-06
dc.identifier.citationHannan, J. M. A., Ojo, O. O., Ali, L., Rokeya, B., Khaleque, J., Akhter, M., Flatt, P. R. and Abdel-Wahab, Y. H. A. (2014) Actions underlying antidiabetic effects of ocimum sanctum leaf extracts in animal models of type 1 and type 2 diabetes, European Journal of Medicinal Plants, 5(1), DOI : 10.9734/EJMP/2015/11840en
dc.identifier.issn2231-0894en
dc.identifier.doi10.9734/ejmp/2015/11840en
dc.identifier.urihttp://hdl.handle.net/2436/622767
dc.description.abstractAim: This study investigated mechanisms by which O. sanctum leaf extracts ameliorate hyperglycaemia using animal and cellular models of diabetes. Place and Duration of Study: Diabetes Research Laboratory, University of Ulster, Coleraine, United Kingdom and Research Division, BIRDEM, Dhaka, Bangladesh; 8 months. Methodology: Acute anti-diabetic effects of ethanolic extracts of O. sanctum were examined in normal and chemically-induced type 1 and 2 diabetic rats. Effects of extracts on glucose absorption, intestinal disaccharidase activity and gastrointestinal motility in type 2 diabetic rats and on glucose uptake and insulin action in 3T3-L1 cells were assessed. Results: Treatment with the extract (1.25 g/kg bw) significantly improved oral glucose tolerance in normal and type 2 diabetic rats and suppressed blood glucose elevation after oral sucrose (2.5 g/kg bw) administration. The extract significantly reduced glucose absorption, gastrointestinal motility and disaccharidase activity. A 28-day treatment with O. sanctum decreased serum glucose, increased liver glycogen and enhanced circulating insulin and total oxidant status in type 2 diabetic rats. Glucose transport and insulin action in 3T3-L1 were increased by extract. Conclusion: O. sanctum represents a useful as a source for discovery of novel antidiabetic compounds and as a dietary adjunct for the management of type 2 diabetes and its complications.en
dc.formatapplication/PDFen
dc.language.isoenen
dc.publisherSciencedomain Internationalen
dc.subjectocimum sanctumen
dc.subject3T3 adipocytesen
dc.subjectintestinal disaccharidase activityen
dc.subjecthepatic glycogenen
dc.subjectglucose uptakeen
dc.titleActions underlying antidiabetic effects of ocimum sanctum leaf extracts in animal models of type 1 and type 2 diabetesen
dc.typeJournal articleen
dc.identifier.journalEuropean Journal of Medicinal Plantsen
dc.date.updated2019-09-20T01:39:53Z
dc.date.accepted2014-07-03
rioxxterms.funderJiscen
rioxxterms.identifier.projectUOW03102019OOen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2019-10-03en
dc.source.volume5
dc.source.issue1
dc.source.beginpage1
dc.source.endpage12
dc.description.versionPublished online
refterms.dateFCD2019-10-03T10:46:22Z
refterms.versionFCDVoR
refterms.dateFOA2019-10-03T10:46:31Z


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