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dc.contributor.authorEngwa, Godwill Azeh
dc.contributor.authorNwalo, Friday Nweke
dc.contributor.authorChibuzor, Gregory Eze
dc.contributor.authorEjiagha, Endaline Chiamaka
dc.contributor.authorAbonyi, Micheal Chinweuba
dc.contributor.authorUgwu, Theophilus Ejiofor
dc.contributor.authorIkechukwu Obiudu, Kenneth
dc.contributor.authorAgbafor, Kingsley Nwonu
dc.contributor.authorOyejide Ojo, Opeolu
dc.contributor.authorEwa Ubi, Benjamin
dc.date.accessioned2019-10-02T14:54:55Z
dc.date.available2019-10-02T14:54:55Z
dc.date.issued2018-08-20
dc.identifier.citationEngwa, G. A. et al. (2018) Relationship between Type 2 Diabetes and Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Their Effect on Oxidative Stress, Journal of Diabetes & Metabolism, 9(8), DOI: 10.4172/2155-6156.1000800en
dc.identifier.issn2155-6156en
dc.identifier.doi10.4172/2155-6156.1000800en
dc.identifier.urihttp://hdl.handle.net/2436/622760
dc.description.abstractObjective: Though the relationship between glucose-6-phosphate dehydrogenase (G6PD) deficiency and type 2 diabetes (T2D) has been reported, their interaction to influence oxidative stress is not fully understood. This study was conducted to investigate the relationship between T2D and G6PD deficiency and assessed their effect on oxidative stress. Methodology: A total of 73 T2D and 75 non-diabetic (ND) out-patients at Enugu State University Teaching Hospital (ESUTH) in Enugu, Nigeria were recruited. They were screened for G6PD deficiency, oxidative stress markers; lipid peroxidation, protein peroxidation and glycated haemoglobin (HbA1c) and antioxidant enzymes; superoxide dismutase (SOD) and catalase activities were assayed. Results: Oxidative stress was influenced by T2D as malondialdehyde (MDA), protein carbonyl and HbA1c levels were significantly higher (p<0.05) in T2D patients compared to ND patients. Significantly (p<0.05) decreased SOD and catalase activity were also observed in T2D patients. G6PD deficiency and T2D showed a significant relationship (p<0.05) in male patients (χ 2=5.070; p=0.024). Moreover, there was no significant (p>0.05) interaction between G6PD deficiency and T2D to influence oxidative stress in patients. Conclusion: The interaction between G6PD deficiency and T2D did not influence oxidative stress though there was a possible relationship between G6PD deficiency and T2D in male patients.en
dc.description.sponsorshipThis study was partially supported by the competitive research grant of Godfrey Okoye University, Enugu Nigeria.en
dc.formatapplication/PDFen
dc.language.isoenen
dc.publisherOMICS Publishing Groupen
dc.subjectG6PD deficiencyen
dc.subjectType 2 diabetesen
dc.subjectoxidative stressen
dc.subjectantioxidantsen
dc.subjectGlycated Haemoglobinen
dc.titleRelationship between Type 2 Diabetes and Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Their Effect on Oxidative Stressen
dc.typeJournal articleen
dc.identifier.journalJournal of Diabetes & Metabolismen
dc.date.updated2019-09-20T00:11:29Z
dc.date.accepted2018-08-14
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW02102019OOen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2019-10-02en
dc.source.volume09
dc.source.issue08
dc.description.versionPublished online
refterms.dateFCD2019-10-02T14:54:46Z
refterms.versionFCDVoR
refterms.dateFOA2019-10-02T14:54:55Z


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