Long noncoding RNA and its contribution to autism spectrum disorders
Abstract
Recent studies have indicated that long noncoding RNAs (lncRNAs) play important roles in multiple processes, such as epigenetic regulation, gene expression regulation, development, nutrition‐related and other diseases, toxic response, and response to drugs. Although the functional roles and mechanisms of several lncRNAs have been discovered, a better understanding of the vast majority of lncRNAs remains elusive. To understand the functional roles and mechanisms of lncRNAs is critical because these transcripts represent the majority of the transcriptional output of the mammalian genome. Recent studies have also suggested that lncRNAs are more abundant in the human brain and are involved in neurodevelopment and neurodevelopmental disorders, including autism spectrum disorders (ASDs). In this study, we review several known functions of lncRNAs and the potential contribution of lncRNAs to ASDs and to other genetic syndromes that have a similar clinical presentation to ASDs, such as fragile X syndrome and Rett syndrome.Citation
Tang, J., Yu, Y. and Yang, W. (2017) Long noncoding RNA and its contribution to autism spectrum disorders, CNS Neuroscience & Therapeutics, 23(8), pp. 645–656.Publisher
WileyJournal
CNS Neuroscience & TherapeuticsAdditional Links
https://onlinelibrary.wiley.com/doi/full/10.1111/cns.12710Type
Journal articleLanguage
enISSN
1755-5930Sponsors
This work was supported by Guangdong Natural Science Foundation (Grant No: 2015A030313455) and National Science Foundation of China (Grant No 81302445).ae974a485f413a2113503eed53cd6c53
10.1111/cns.12710
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