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dc.contributor.authorGeorgakouli, K
dc.contributor.authorManthou, E
dc.contributor.authorFatouros, IG
dc.contributor.authorGeorgoulias, P
dc.contributor.authorDeli, CK
dc.contributor.authorKoutedakis, Y
dc.contributor.authorTheodorakis, Y
dc.contributor.authorJamurtas, AZ
dc.date.accessioned2019-08-27T11:47:06Z
dc.date.available2019-08-27T11:47:06Z
dc.date.issued2017-12-02
dc.identifier.citationGeorgakouli, A. (2018) Enhanced erythrocyte antioxidant status following an 8-week aerobic exercise training program in heavy drinkers, Alcohol, 69 (June 2018), pp. 57-62.en
dc.identifier.issn0741-8329en
dc.identifier.pmid29653379
dc.identifier.doi10.1016/j.alcohol.2017.11.035en
dc.identifier.urihttp://hdl.handle.net/2436/622683
dc.description.abstract© 2017 Elsevier Inc. Alcohol-induced oxidative stress is involved in the development and progression of various pathological conditions and diseases. On the other hand, exercise training has been shown to improve redox status, thus attenuating oxidative stress-associated disease processes. The purpose of the present study was to evaluate the effect of an exercise training program that has been previously reported to decrease alcohol consumption on blood redox status in heavy drinkers. In a non-randomized within-subject design, 11 sedentary, heavily drinking men (age: 30.3 ± 3.5 years; BMI: 28.4 ± 0.86 kg/m2) participated first in a control condition for 4 weeks, and then in an intervention where they completed an 8-week supervised aerobic training program of moderate intensity (50–60% of the heart rate reserve). Blood samples were collected in the control condition (pre-, post-control) as well as before, during (week 4 of the training program), and after intervention (week 8 of the training program). Samples were analyzed for total antioxidant capacity (TAC), thiobarbituric acid reactive substances (TBARS), protein carbonyls (PC), uric acid (UA), bilirubin, reduced glutathione (GSH), and catalase activity. No significant change in indices of redox status in the pre- and post-control was observed. Catalase activity increased (p < 0.05) after 8 weeks of intervention compared to week 4. GSH increased (p < 0.05) after 8 weeks of intervention compared to the control condition and to week 4 of intervention. TAC, UA, bilirubin, TBARS, and PC did not significantly change at any time point. Moreover, concentrations of GSH, TBARS, and catalase activity negatively correlated with alcohol consumption. In conclusion, an 8-week aerobic training program enhanced erythrocyte antioxidant status in heavy drinkers, indicating that aerobic training may attenuate pathological processes caused by alcohol-induced oxidative stress.en
dc.description.sponsorshipThis study was co-financed by the European Union [European Social Fund (ESF)] and Greek national funds through the Operational Program ‘Education and Lifelong Learning’ of the National Strategic Reference Framework-Research Funding Program: THALES. Investing in knowledge society through the ESF.en
dc.formatapplication/PDFen
dc.languageeng
dc.language.isoenen
dc.publisherElsevier BVen
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0741832917309035?via%3Dihuben
dc.subjectAlcoholen
dc.subjectAbuseen
dc.subjectAlcohol-use disordersen
dc.subjectFree radicalsen
dc.subjectOxidative stressen
dc.titleEnhanced erythrocyte antioxidant status following an 8-week aerobic exercise training program in heavy drinkersen
dc.typeJournal articleen
dc.identifier.eissn1873-6823
dc.identifier.journalAlcoholen
dc.date.updated2019-08-22T17:40:21Z
dc.contributor.institutionDepartment of Physical Education and Sport Science, University of Thessaly, Karies, Trikala 42100, Greece; Institute of Human Performance and Rehabilitation, Centre for Research and Technology - Thessaly (CERETETH), Karies, Trikala 42100, Greece. Electronic address: kgeorgakouli@gmail.com.
pubs.place-of-publicationUnited States
dc.date.accepted2017-11-22
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW270819YKen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2019-08-27en
dc.source.volume69
dc.source.beginpage57
dc.source.endpage62
dc.description.versionPublished version
refterms.dateFCD2019-08-27T11:46:12Z
refterms.versionFCDAM
refterms.dateFOA2019-08-27T11:47:06Z


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