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dc.contributor.authorStavrou, V
dc.contributor.authorBoutou, AK
dc.contributor.authorVavougios, GD
dc.contributor.authorPastaka, C
dc.contributor.authorGourgoulianis, KI
dc.contributor.authorKoutedakis, Y
dc.contributor.authorDaniil, Z
dc.contributor.authorKaretsi, E
dc.date.accessioned2019-08-22T10:24:38Z
dc.date.available2019-08-22T10:24:38Z
dc.date.issued2019-01-23
dc.identifier.citationStavrou, V., Boutou, A. K., Vavougios, G. D., Konstantinos, Pastaka, C., Gourgoulianis, K. I., Koutedakis, Y., Daniil, Z. and Karetsi, E. (2019) The use of cardiopulmonary exercise testing in identifying the presence of obstructive sleep apnea syndrome in patients with compatible symptomatology, Respiratory Physiology and Neurobiology, 262, pp. 26-31.en
dc.identifier.issn1569-9048en
dc.identifier.pmid30684645
dc.identifier.doi10.1016/j.resp.2019.01.010en
dc.identifier.urihttp://hdl.handle.net/2436/622675
dc.description.abstract© 2019 The aim of this study was to investigate the relationship between cardiopulmonary exercise testing (CPET) and the presence of obstructive sleep apnea syndrome (OSAS) in order to provide an innovative tool to identify patients with OSAS. A prospective nested case control design was adopted. A consecutive population of male volunteers referred to a Sleep Unit was subjected to nocturnal polysomnography, full lung function testing and maximal CPET. A stepwise linear discriminant function analysis (DFA) was applied to construct a model which could identify individuals with moderate-to-severe OSAS from healthy controls. The total of 30 volunteers formed the OSAS and 24 the non-OSAS groups. Demographic and somatometric parameters were similar between groups. Patients presented with lower Expiratory Reserve Volume (ERV: 106.7 ± 28.3 vs. 123.9 ± 22.1, p < 0.001), Leg Fatigue Borg scale (3.9 ± 1.1 vs. 6.1 ± 1.4, p < 0.001), VO 2peak (25.0 ± 5.9 vs. 32.9 ± 7.2 ml/kg −1 /min −1 , p < 0.001), peak breathing frequency (31.0 ± 5.8 vs. 35.5 ± 7.3 1/min −1 , p < 0.001) and peak heart rate (151.1 ± 17.7 vs. 171.2 ± 12.6 beats/min −1 , p < 0.001) compared to controls, but higher peak end-tidal CO 2 (P ET CO 2peak :38.6 ± 4.2 vs. 35.0 ± 4.9 mmHg, p = 0.043) and peak systolic (SBP:188.3 ± 21.9 vs. 173.1 ± 17.9 mmHg, p = 0.009) and diastolic (DBP: 91.3 ± 8.2 vs. 85.4 ± 8.2 mmHg, p = 0.011) blood pressure. Stepwise DFA indicated that ERV % of predicted (0.372), P ET CO 2peak (−0.376), SpO 2resting (0.0667), Leg Fatigue Borg scale (0.564), HR peak (0.530) and DBP peak (−0.543) could separate the two groups, with an overall predictive accuracy of 96.3%. Selected CPET parameters (ERV % of predicted , P ET CO 2peak , SpO 2resting , HR peak , DBP peak and Leg Fatigue Borg Scale ) are independently associated with OSAS presence and could discriminate patients with and without this disorder.en
dc.formatapplication/PDFen
dc.languageeng
dc.language.isoenen
dc.publisherElsevier BVen
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S1569904818304063?via%3Dihuben
dc.subjectCardiopulmonary exercise testingen
dc.subjectObstructive sleep apnea syndromeen
dc.titleThe use of cardiopulmonary exercise testing in identifying the presence of obstructive sleep apnea syndrome in patients with compatible symptomatologyen
dc.typeJournal articleen
dc.identifier.eissn1878-1519
dc.identifier.journalRespiratory Physiology and Neurobiologyen
dc.date.updated2019-08-20T13:31:23Z
dc.contributor.institutionLaboratory of Cardiopulmonary Testing, Department of Respiratory Medicine, University of Thessaly, Larissa, Greece. Electronic address: vasileiosstavrou@hotmail.com.
pubs.place-of-publicationNetherlands
dc.date.accepted2019-01-22
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW220819YKen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2020-01-23en
dc.source.volume262
dc.source.beginpage26
dc.source.endpage31
dc.description.versionPublished version
refterms.dateFCD2019-08-22T10:22:38Z
refterms.versionFCDAM


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