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dc.contributor.authorGupta, A
dc.contributor.authorKeddie, DJ
dc.contributor.authorKannappan, V
dc.contributor.authorGibson, H
dc.contributor.authorKhalil, IR
dc.contributor.authorKowalczuk, M
dc.contributor.authorMartin, C
dc.contributor.authorShuai, X
dc.contributor.authorRadecka, I
dc.date.accessioned2019-07-10T13:43:12Z
dc.date.available2019-07-10T13:43:12Z
dc.date.issued2019-06-14
dc.identifier.citationGupta, A. et al (2019) Production and characterisation of bacterial cellulose hydrogels loaded with curcumin encapsulated in cyclodextrins as wound dressings, European Polymer Journal (118)September 2019, pp437-450en
dc.identifier.issn0014-3057en
dc.identifier.doi10.1016/j.eurpolymj.2019.06.018en
dc.identifier.urihttp://hdl.handle.net/2436/622532
dc.description.abstract© 2019 Elsevier Ltd Natural bioactive materials with wound healing properties such as curcumin are attracting interest due to the emergence of resistant bacterial strains. The hydrophobicity of curcumin has been counteracted by using solubility enhancing cyclodextrins. Hydrogels facilitate wound healing due to unique properties and 3D network structures which allows encapsulation of healing agents. In this study, biosynthetic cellulose produced by Gluconacetobacter xylinus (ATCC 23770) was loaded with water soluble curcumin:hydroxypropyl-β-cyclodextrin supramolecular inclusion complex produced by a solvent evaporation method to synthesise hydrogel dressings. The ratios of solvents to solubilise curcumin and hydroxypropyl-β-cyclodextrin were tested for the production of the inclusion complex with optimum encapsulation efficacy. The results confirmed that hydroxypropyl-β-cyclodextrin enhanced the aqueous solubility of curcumin and allowed loading into bacterial cellulose hydrogels. These hydrogels were characterised for wound management applications and exhibited haemocompatability, cytocompatability, anti-staphylococcal and antioxidant abilities and therefore support the potential use of the curcumin:hydroxypropyl-β-cyclodextrin-loaded-bacterial cellulose as hydrogel dressings.en
dc.formatapplication/pdfen
dc.languageen
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0014305719307803en
dc.subjectbiosynthetic hydrogelen
dc.subjectcurcuminen
dc.subjectcyclodextrinen
dc.subjectantimicrobialen
dc.subjectantioxidanten
dc.subjectwound managementen
dc.titleProduction and characterisation of bacterial cellulose hydrogels loaded with curcumin encapsulated in cyclodextrins as wound dressingsen
dc.typeJournal articleen
dc.identifier.journalEuropean Polymer Journalen
dc.date.updated2019-07-05T10:21:48Z
dc.date.accepted2019-06-14
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.project100719IRen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2021-06-14en
dc.source.volume118
dc.source.beginpage437
dc.source.endpage450
dc.description.versionAccepted version
refterms.dateFCD2019-07-10T13:42:36Z
refterms.versionFCDAM


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