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dc.contributor.authorStebbings, Georgina K*
dc.contributor.authorWilliams, AG*
dc.contributor.authorMorse, CI*
dc.contributor.authorDay, SH*
dc.date.accessioned2019-06-12T11:35:06Z
dc.date.available2019-06-12T11:35:06Z
dc.date.issued2017-03-01
dc.identifier.citationStebbings, G. K., Williams, A. G., Morse, C. I. and Day, S. H. (2017) Polymorphisms in PTK2 are associated with skeletal muscle specific force: an independent replication study, European Journal of Applied Physiology, 117(4), pp. 713-720.en
dc.identifier.issn1439-6319en
dc.identifier.doi10.1007/s00421-017-3567-3en
dc.identifier.urihttp://hdl.handle.net/2436/622438
dc.description.abstractPurpose The aim of the study was to investigate two single nucleotide polymorphisms (SNP) in PTK2 for associations with human muscle strength phenotypes in healthy men. Methods Measurement of maximal isometric voluntary knee extension (MVCKE) torque, net MVCKE torque and vastus lateralis (VL) specific force, using established techniques, was completed on 120 Caucasian men (age = 20.6 ± 2.3 year; height = 1.79 ± 0.06 m; mass = 75.0 ± 10.0 kg; mean ± SD). All participants provided either a blood (n = 96) or buccal cell sample, from which DNA was isolated and genotyped for the PTK2 rs7843014 A/C and rs7460 A/T SNPs using real-time polymerase chain reaction. Results Genotype frequencies for both SNPs were in Hardy–Weinberg equilibrium (X 2 ≤ 1.661, P ≥ 0.436). VL specific force was 8.3% higher in rs7843014 AA homozygotes than C-allele carriers (P = 0.017) and 5.4% higher in rs7460 AA homozygotes than T-allele carriers (P = 0.029). No associations between either SNP and net MVCKE torque (P ≥ 0.094) or peak MVCKE torque (P ≥ 0.107) were observed. Conclusions These findings identify a genetic contribution to the inter-individual variability within muscle specific force and provides the first independent replication, in a larger Caucasian cohort, of an association between these PTK2 SNPs and muscle specific force, thus extending our understanding of the influence of genetic variation on the intrinsic strength of muscle.en
dc.formatapplication/PDFen
dc.languageen
dc.language.isoenen
dc.publisherSpringer Natureen
dc.relation.urlhttps://link.springer.com/article/10.1007%2Fs00421-017-3567-3en
dc.subjectvastus lateralisen
dc.subjectprotein tyrosine kinase 2en
dc.subjectlateral transmissionen
dc.subjectfocal adhesion kinaseen
dc.subjectmuscle qualityen
dc.subjectgenetic polymorphismen
dc.titlePolymorphisms in PTK2 are associated with skeletal muscle specific force: an independent replication studyen
dc.typeJournal articleen
dc.identifier.eissn1439-6327
dc.identifier.journalEuropean Journal of Applied Physiologyen
dc.date.updated2019-06-04T08:14:32Z
dc.date.accepted2017-02-08
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW120619SDen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2019-06-12en
dc.source.volume117
dc.source.issue4
dc.source.beginpage713
dc.source.endpage720
dc.description.versionPublished version
refterms.dateFCD2019-06-12T11:33:38Z
refterms.versionFCDVoR
refterms.dateFOA2019-06-12T11:35:08Z


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