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dc.contributor.authorPandey, M
dc.contributor.authorMohamad, N
dc.contributor.authorLow, WL
dc.contributor.authorMartin, C
dc.contributor.authorMohd Amin, MCI
dc.date.accessioned2019-06-05T10:27:20Z
dc.date.available2019-06-05T10:27:20Z
dc.date.issued2017-02-01
dc.identifier.citationPandey, M., Mohamad, N., Low, WL. et al. Drug Deliv. and Transl. Res. (2017) 7: 89. https://doi.org/10.1007/s13346-016-0341-8en
dc.identifier.issn2190-393Xen
dc.identifier.pmid27815776
dc.identifier.doi10.1007/s13346-016-0341-8en
dc.identifier.urihttp://hdl.handle.net/2436/622411
dc.description.abstract© 2016, Controlled Release Society. Burn wound management is a complex process because the damage may extend as far as the dermis which has an acknowledged slow rate of regeneration. This study investigates the feasibility of using hydrogel microparticles composed of bacterial cellulose and polyacrylamide as a dressing material for coverage of partial-thickness burn wounds. The microparticulate carrier structure and surface morphology were investigated by Fourier transform infrared, X-ray diffraction, elemental analysis, and scanning electron microscopy. The cytotoxicity profile of the microparticles showed cytocompatibility with L929 cells. Dermal irritation test demonstrated that the hydrogel was non-irritant to the skin and had a significant effect on wound contraction compared to the untreated group. Moreover, histological examination of in vivo burn healing samples revealed that the hydrogel treatment enhanced epithelialization and accelerated fibroblast proliferation with wound repair and intact skin achieved by the end of the study. Both the in vitro and in vivo results proved the biocompatibility and efficacy of hydrogel microparticles as a wound dressing material.en
dc.formatapplication/PDFen
dc.languageeng
dc.language.isoenen
dc.publisherSpringer Natureen
dc.relation.urlhttps://link.springer.com/article/10.1007%2Fs13346-016-0341-8en
dc.subjectCell Lineen
dc.subjectSkinen
dc.subjectAnimalsen
dc.subjectMiceen
dc.subjectRats, Sprague-Dawleyen
dc.subjectBacteriaen
dc.subjectBurnsen
dc.subjectCelluloseen
dc.subjectAcrylic Resinsen
dc.subjectHydrogelsen
dc.subjectDrug Carriersen
dc.subjectSkin Irritancy Testsen
dc.subjectWound Healingen
dc.subjectCell Survivalen
dc.subjectMicrowavesen
dc.subjectFemaleen
dc.titleMicrowaved bacterial cellulose-based hydrogel microparticles for the healing of partial thickness burn woundsen
dc.typeJournal articleen
dc.identifier.eissn2190-3948
dc.identifier.journalDrug Delivery and Translational Researchen
dc.date.updated2019-05-30T08:30:10Z
dc.contributor.institutionSchool of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.
pubs.place-of-publicationUnited States
dc.date.accepted2016-10-19
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW050619WLLen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2019-06-05en
dc.source.volume7
dc.source.issue1
dc.source.beginpage89
dc.source.endpage99
dc.description.versionPublished version
refterms.dateFCD2019-06-05T10:24:34Z
refterms.versionFCDAM
refterms.dateFOA2019-06-05T10:27:21Z


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