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dc.contributor.authorKite, Chris
dc.contributor.authorLahart, Ian M
dc.contributor.authorAfzal, Islam
dc.contributor.authorBroom, David R
dc.contributor.authorRandeva, Harpal
dc.contributor.authorKyrou, Ioannis
dc.contributor.authorBrown, James E
dc.date.accessioned2019-03-06T11:22:20Z
dc.date.available2019-03-06T11:22:20Z
dc.date.issued2019-02-12
dc.identifier.citationKite, C. et al (2019) Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis, Systematic Reviews 2019 8:51 https://doi.org/10.1186/s13643-019-0962-3en
dc.identifier.issn2046-4053en
dc.identifier.pmid30755271
dc.identifier.doi10.1186/s13643-019-0962-3
dc.identifier.urihttp://hdl.handle.net/2436/622165
dc.description.abstractTypically, management of PCOS focuses on lifestyle changes (exercise and diet), aiming to alleviate symptoms, and lower the associated risk of type 2 diabetes and cardiovascular disease. Our objective was to analyse evidence on the effectiveness of exercise in the management of PCOS, when compared to (i) usual care, (ii) diet alone, and (iii) exercise combined with diet, and also exercise combined with diet, compared to (i) control or usual care and (ii) diet alone. Relevant databases were searched (June 2017) with no time limit for trial inclusion. Eligible trials employed a randomised or quasi-randomised design to measure the chronic effects of exercise, or exercise and diet in women with PCOS. Searches returned 2390 articles; of those, 27 papers from 18 trials were included. Results are presented as mean difference (MD) and 95% confidence intervals (95% CI). Compared with control, exercise had a statistical effect on change from baseline fasting insulin (MD - 2.44 μIU/mL, 95% CIs - 4.24 to - 0.64; very low-quality evidence), HOMA-IR (- 0.57, - 0.99 to - 0.14; very low-quality evidence), total cholesterol (- 5.88 mg/dL, - 9.92 to - 1.83; low-quality evidence), LDL cholesterol (- 7.39 mg/dL, - 9.83 to - 4.95; low-quality evidence), and triglycerides (- 4.78 mg/dL, - 7.52 to - 2.05; low-quality evidence). Exercise also improved VO Statistically beneficial effects of exercise were found for a range of metabolic, anthropometric, and cardiorespiratory fitness-related outcomes. However, caution should be adopted when interpreting these findings since many outcomes present modest effects and wide CIs, and statistical effects in many analyses are sensitive to the addition/removal of individual trials. Future work should focus on rigorously designed, well-reported trials that make comparisons involving both exercise and diet.en
dc.formatapplication/PDFen
dc.language.isoenen
dc.publisherBMCen
dc.relation.urlhttps://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-019-0962-3en
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectCardiorespiratory fitnessen
dc.subjectCardiovascular risken
dc.subjectDieten
dc.subjectExerciseen
dc.subjectInsulin resistanceen
dc.subjectPhysical activityen
dc.subjectPolycystic ovary syndromeen
dc.titleExercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis.en
dc.typeJournal article
dc.identifier.journalSystematic Reviewsen
dc.date.accepted2019-01-23
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectuow060319ILen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2019-03-06en
dc.source.journaltitleSystematic reviews
dc.source.volume8
dc.source.issue1
dc.source.beginpage1
dc.source.endpage28
refterms.dateFCD2019-03-06T11:22:21Z
refterms.versionFCDVoR
refterms.dateFOA2019-03-06T11:22:21Z


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