Impacts of overweight and obesity in older age on the risk of dementia: A systematic literature review and a meta-analysis
Authors
Danat, Isaac MClifford, Angela
Partridge, Martin
Zhou, Weiju
Bakre, Aishat
Chen, Anthony
McFeeters, Danielle
Smith, Tina
Wan, Yuhui
Copeland, John
Ruoling, Chen
Anstey, Kaarin J.
Smith, Tina
Issue Date
2019-01-21
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Background: It is unclear whether overweight and obesity in older age reduces or increases the risk of incident dementia. Objective: To assess the impacts of overweight and obesity in older age on incident dementia. Methods: We searched cohort studies reporting body weight measured in older age and dementia through PubMed, Embase, Medline, PyschInfo, and Cochrane library until July 2016. Sixteen articles were identified for the review. We pooled data from them and a new unpublished study from China, to calculate relative risk (RR) of incident dementia in relation to body mass index (BMI) and waist circumference (WC). Results: All 16 cohort studies were undertaken in high income countries, with follow-up periods ranging between 3 to 18 years. Thirteen studies showed an inverse association between BMI and dementia, and three studies demonstrated a positive association. Pooled RR of dementia in relation to continuous BMI from 14 studied populations, including the new Chinese data was 0.97 (95% CI 0.95–1.00); in those with followed up <9 years was 0.95 (0.93–0.96) while in ≥9 years follow-up was 1.03 (0.96–1.11). In five studied populations examining categorical BMI, RR of dementia in older people classified as overweight and obese was 0.98 (0.54–1.77) and 1.17 (0.65–2.10) respectively, in comparison with other weights. The pooled WC data showed no association between increased WC and reduced risk of dementia. Conclusion: The current evidence did not support a paradox on beneficial impacts of overweight and obesity in older age on incident dementia. More studies with long term follow up are needed to clarify the association of body weight in older age with dementia risk.Citation
Danat, I.M. et al (2019) Impacts of Overweight and Obesity in Older Age on the Risk of Dementia: A Systematic Literature Review and a Meta-Analysis, Journal of Alzheimer's Disease DOI 10.3233/JAD-180763Publisher
IOS pressJournal
Journal of Alzheimer's DiseaseType
Journal articleLanguage
enISSN
1387-2877ae974a485f413a2113503eed53cd6c53
10.3233/JAD-180763
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