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dc.contributor.authorGeorgakouli, Kalliopi
dc.contributor.authorFatouros, Ioannis G.
dc.contributor.authorFragkos, Apostolos
dc.contributor.authorTzatzakis, Theofanis
dc.contributor.authorDeli, Chariklia K.
dc.contributor.authorPapanikolaou, Konstantinos
dc.contributor.authorKoutedakis, Yiannis
dc.contributor.authorJamurtas, Athanasios Z.
dc.date.accessioned2019-01-16T15:43:14Z
dc.date.available2019-01-16T15:43:14Z
dc.date.issued2018-11-12
dc.identifier.citationGeorgakouli, K., Fatouros, I., Fragkos, A., Tzatzakis, T., Deli, C., Papanikolaou, K., Koutedakis, Y. and Jamurtas, A. (2018). Exercise and Redox Status Responses Following Alpha-Lipoic Acid Supplementation in G6PD Deficient Individuals. Antioxidants, 7(11), p.162.en
dc.identifier.issn2076-3921en
dc.identifier.doi10.3390/antiox7110162
dc.identifier.urihttp://hdl.handle.net/2436/622060
dc.description.abstractG6PD deficiency renders cells more susceptible to oxidative insults, while antioxidant dietary supplementation could restore redox balance and ameliorate exercise-induced oxidative stress. To examine the effects of alpha-lipoic acid (ALA) supplementation on redox status indices in G6PD deficient individuals, eight male adults with G6PD deficiency (D) participated in this randomized double-blind placebo-controlled crossover trial. Participants were randomly assigned to receive ALA (600 mg/day) or placebo for 4 weeks separated by a 4-week washout period. Before and at the end of each treatment period, participants exercised following an exhaustive treadmill exercise protocol. Blood samples were obtained before (at rest), immediately after and 1h after exercise for later analysis of total antioxidant capacity (TAC), uric acid, bilirubin, thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PC). ALA resulted in significantly increased resting TAC and bilirubin concentrations. Moreover, TAC increased immediately and 1h after exercise following both treatment periods, whereas bilirubin increased immediately after and 1h after exercise following only ALA. No significant change in uric acid, TBARS or PC was observed at any time point. ALA supplementation for 4 weeks may enhance antioxidant status in G6PD individuals; however, it does not affect redox responses to acute exercise until exhaustion or exercise performance.en
dc.formatapplication/PDFen
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urlhttps://www.mdpi.com/2076-3921/7/11/162en
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectantioxidantsen
dc.subjectenzymopathyen
dc.subjectoxidative stressen
dc.subjectexercise performanceen
dc.subjectmuscleen
dc.titleExercise and redox status responses following alpha-lipoic acid supplementation in G6PD deficient individualsen
dc.typeJournal article
dc.identifier.journalAntioxidantsen
dc.date.accepted2018-11-02
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW160119YKen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2019-01-16en
dc.source.volume7
dc.source.issue11
dc.source.beginpage162
dc.source.endpage171
refterms.dateFCD2019-01-16T15:43:15Z
refterms.versionFCDAM
refterms.dateFOA2019-01-16T15:43:15Z


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