Exercise and redox status responses following alpha-lipoic acid supplementation in G6PD deficient individuals
Authors
Georgakouli, KalliopiFatouros, Ioannis G.
Fragkos, Apostolos
Tzatzakis, Theofanis
Deli, Chariklia K.
Papanikolaou, Konstantinos
Koutedakis, Yiannis
Jamurtas, Athanasios Z.
Issue Date
2018-11-12
Metadata
Show full item recordAbstract
G6PD deficiency renders cells more susceptible to oxidative insults, while antioxidant dietary supplementation could restore redox balance and ameliorate exercise-induced oxidative stress. To examine the effects of alpha-lipoic acid (ALA) supplementation on redox status indices in G6PD deficient individuals, eight male adults with G6PD deficiency (D) participated in this randomized double-blind placebo-controlled crossover trial. Participants were randomly assigned to receive ALA (600 mg/day) or placebo for 4 weeks separated by a 4-week washout period. Before and at the end of each treatment period, participants exercised following an exhaustive treadmill exercise protocol. Blood samples were obtained before (at rest), immediately after and 1h after exercise for later analysis of total antioxidant capacity (TAC), uric acid, bilirubin, thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PC). ALA resulted in significantly increased resting TAC and bilirubin concentrations. Moreover, TAC increased immediately and 1h after exercise following both treatment periods, whereas bilirubin increased immediately after and 1h after exercise following only ALA. No significant change in uric acid, TBARS or PC was observed at any time point. ALA supplementation for 4 weeks may enhance antioxidant status in G6PD individuals; however, it does not affect redox responses to acute exercise until exhaustion or exercise performance.Citation
Georgakouli, K., Fatouros, I., Fragkos, A., Tzatzakis, T., Deli, C., Papanikolaou, K., Koutedakis, Y. and Jamurtas, A. (2018). Exercise and Redox Status Responses Following Alpha-Lipoic Acid Supplementation in G6PD Deficient Individuals. Antioxidants, 7(11), p.162.Publisher
MDPIJournal
AntioxidantsAdditional Links
https://www.mdpi.com/2076-3921/7/11/162Type
Journal articleLanguage
enISSN
2076-3921ae974a485f413a2113503eed53cd6c53
10.3390/antiox7110162
Scopus Count
Collections
The following licence applies to the copyright and re-use of this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States